The human papillomavirus replication cycle, and its links to cancer progression: a comprehensive review

SV Graham - Clinical science, 2017 - portlandpress.com
HPVs (human papillomaviruses) infect epithelial cells and their replication cycle is intimately
linked to epithelial differentiation. There are over 200 different HPV genotypes identified to …

Human papillomavirus molecular biology and disease association

J Doorbar, N Egawa, H Griffin… - Reviews in medical …, 2015 - Wiley Online Library
Human papillomaviruses (HPVs) have evolved over millions of years to propagate
themselves in a range of different animal species including humans. Viruses that have co …

The biology and life-cycle of human papillomaviruses

J Doorbar, W Quint, L Banks, IG Bravo, M Stoler… - Vaccine, 2012 - Elsevier
Human papillomaviruses (HPVs) comprise a diverse group, and have different epithelial
tropisms and life-cycle strategies. Many HPVs are classified as low-risk, as they are only …

[HTML][HTML] The E4 protein; structure, function and patterns of expression

J Doorbar - Virology, 2013 - Elsevier
The papillomavirus E4 open reading frame (ORF) is contained within the E2 ORF, with the
primary E4 gene-product (E1∧ E4) being translated from a spliced mRNA that includes the …

Productive lifecycle of human papillomaviruses that depends upon squamous epithelial differentiation

N Kajitani, A Satsuka, A Kawate, H Sakai - Frontiers in microbiology, 2012 - frontiersin.org
Human papillomaviruses (HPVs) target the stratified epidermis, and can causes diseases
ranging from benign condylomas to malignant tumors. Infections of HPVs in the genital tract …

Keratinocyte differentiation-dependent human papillomavirus gene regulation

SV Graham - Viruses, 2017 - mdpi.com
Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive
cancers. HPVs infect epithelial cells and their replication cycle is tightly linked with the …

Mechanisms by which HPV induces a replication competent environment in differentiating keratinocytes

CA Moody - Viruses, 2017 - mdpi.com
Human papillomaviruses (HPV) are the causative agents of cervical cancer and are also
associated with other genital malignancies, as well as an increasing number of head and …

Human papillomavirus and the DNA damage response: exploiting host repair pathways for viral replication

CC Spriggs, LA Laimins - Viruses, 2017 - mdpi.com
High-risk human papillomaviruses (HPVs) are the causative agents of cervical and other
genital cancers. In addition, HPV infections are associated with the development of many …

Oncogenic human papillomavirus imposes an instructive pattern of DNA methylation changes which parallel the natural history of cervical HPV infection in young …

SM Leonard, W Wei, SI Collins, M Pereira… - …, 2012 - academic.oup.com
The contribution of early virus-induced epigenetic changes to human papillomavirus (HPV)-
associated carcinogenesis is poorly understood. Using genome-wide methylation array …

Disruption of CTCF-YY1–dependent looping of the human papillomavirus genome activates differentiation-induced viral oncogene transcription

I Pentland, K Campos-León, M Cotic, KJ Davies… - PLoS …, 2018 - journals.plos.org
The complex life cycle of oncogenic human papillomavirus (HPV) initiates in undifferentiated
basal epithelial keratinocytes where expression of the E6 and E7 oncogenes is restricted …