Diffusion tensor imaging of white matter degeneration in Alzheimer's disease and mild cognitive impairment
Alzheimer's disease (AD) has traditionally been regarded as a disease of the gray matter
(GM). However, the advent of diffusion tensor imaging (DTI) has contributed to new …
(GM). However, the advent of diffusion tensor imaging (DTI) has contributed to new …
Dendritic spines in Alzheimer's disease: how the actin cytoskeleton contributes to synaptic failure
S Pelucchi, R Stringhi, E Marcello - International journal of molecular …, 2020 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by Aβ-driven
synaptic dysfunction in the early phases of pathogenesis. In the synaptic context, the actin …
synaptic dysfunction in the early phases of pathogenesis. In the synaptic context, the actin …
[HTML][HTML] Arizona study of aging and neurodegenerative disorders and brain and body donation program
Abstract The Brain and Body Donation Program (BBDP) at Banner Sun Health Research
Institute (http://www. brainandbodydonationprogram. org) started in 1987 with brain-only …
Institute (http://www. brainandbodydonationprogram. org) started in 1987 with brain-only …
Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer's disease
Rapidly progressive Alzheimer's disease (rpAD) is a particularly aggressive form of
Alzheimer's disease, with a median survival time of 7–10 months after diagnosis. Why these …
Alzheimer's disease, with a median survival time of 7–10 months after diagnosis. Why these …
Ependymal cells and neurodegenerative disease: outcomes of compromised ependymal barrier function
DG Nelles, LN Hazrati - Brain communications, 2022 - academic.oup.com
Within the central nervous system, ependymal cells form critical components of the blood-
cerebrospinal fluid barrier and the cerebrospinal fluid-brain barrier. These barriers provide …
cerebrospinal fluid barrier and the cerebrospinal fluid-brain barrier. These barriers provide …
Fascin in cell migration: more than an actin bundling protein
Simple Summary Cell migration is an essential biological process that regulates both
development and diseases, such as cancer metastasis. Therefore, understanding the factors …
development and diseases, such as cancer metastasis. Therefore, understanding the factors …
β-Synuclein: An enigmatic protein with diverse functionality
J Hayashi, JA Carver - Biomolecules, 2022 - mdpi.com
α-Synuclein (αS) is a small, unstructured, presynaptic protein expressed in the brain. Its
aggregated form is a major component of Lewy bodies, the large proteinaceous deposits in …
aggregated form is a major component of Lewy bodies, the large proteinaceous deposits in …
TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway
Background Microglia, the innate immune cells in the central nervous system, play an
essential role in brain homeostasis, neuroinflammation and brain infections. Dysregulated …
essential role in brain homeostasis, neuroinflammation and brain infections. Dysregulated …
Soluble amyloid beta levels are elevated in the white matter of Alzheimer's patients, independent of cortical plaque severity
LE Collins-Praino, YI Francis, EY Griffith… - Acta neuropathologica …, 2014 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disease and the leading
cause of dementia. In addition to grey matter pathology, white matter changes are now …
cause of dementia. In addition to grey matter pathology, white matter changes are now …
Myelin changes at the early stage of 5XFAD mice
Previous studies have demonstrated myelin deficits in Alzheimer's disease (AD). However, it
is still unclear whether myelin deficits occur at early stage of AD. Our study aimed to …
is still unclear whether myelin deficits occur at early stage of AD. Our study aimed to …