Simulating cancer behavior across multiple biological scales in space and time, ie,
multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine …

The most lethal form of brain cancer, glioblastoma multiforme, is characterized by rapid
growth and invasion facilitated by cell migration and degradation of the extracellular matrix …

Despite major scientific, medical and technological advances over the last few decades, a
cure for cancer remains elusive. The disease initiation is complex, and including initiation …

Mathematical modeling, analysis and simulation are set to play crucial roles in explaining
tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial …

Cancer research attracts broad resources and scientists from many disciplines, and has
produced some impressive advances in the treatment and understanding of this disease …

Effective translational methodologies for knowledge representation are needed in order to
make strides against the constellation of diseases that affect the world today. These …

Ductal carcinoma in situ (DCIS)—a significant precursor to invasive breast cancer—is
typically diagnosed as microcalcifications in mammograms. However, the effective use of …

Glioblastomas are the most aggressive primary brain tumors, characterized by their rapid
proliferation and diffuse infiltration of the brain tissue. Survival patterns in patients with …

The aim of systems biology is to describe and understand biology at a global scale where
biological functions are recognised as a result of complex mechanisms that happen at …

Abstract Systems Biology has taken advantage of computational tools and high-throughput
experimental data to model several biological processes. These include signaling, gene …