The potential therapeutic value of medicinal plants in the management of metabolic disorders

TT Nyakudya, T Tshabalala, R Dangarembizi… - Molecules, 2020 - mdpi.com
Metabolic syndrome (MetS) is a prevalent, multifactorial and complex disease that is
associated with an increased risk of developing diabetes and other major cardiovascular …

[HTML][HTML] Prophylactic and therapeutic roles of oleanolic acid and its derivatives in several diseases

A Sen - World Journal of Clinical Cases, 2020 - ncbi.nlm.nih.gov
Oleanolic acid (OA) and its derivatives are widely found in diverse plants and are naturally
effective pentacyclic triterpenoid compounds with broad prophylactic and therapeutic roles …

Oleanolic acid targets the gut–liver axis to alleviate metabolic disorders and hepatic steatosis

C Xue, Y Li, H Lv, L Zhang, C Bi, N Dong… - Journal of Agricultural …, 2021 - ACS Publications
This study investigated the effects of oleanolic acid (OA) on hepatic lipid metabolism and gut–
liver axis homeostasis in an obesity-related non-alcoholic fatty liver disease (NAFLD) …

Protective role of probiotic supplements in hepatic steatosis: a rat model study

A Azarang, O Farshad, MM Ommati… - BioMed Research …, 2020 - Wiley Online Library
Background. Treating nonalcoholic fatty liver disease (NAFLD) is considered one of the
public health priorities in the past decade. So far, probiotics have represented promising …

A nanosensitizer self-assembled from oleanolic acid and chlorin e6 for synergistic chemo/sono-photodynamic cancer therapy

Y Zheng, Z Li, Y Yang, H Shi, H Chen, Y Gao - Phytomedicine, 2021 - Elsevier
Background Sono-photodynamic therapy (SPDT) which is the combination of photodynamic
therapy (PDT) and sonodynamic therapy (SDT), could exert much better anti-cancer effects …

Molecular mechanisms underlying the effects of olive oil triterpenic acids in obesity and related diseases

CM Claro-Cala, F Jiménez-Altayó, S Zagmutt… - Nutrients, 2022 - mdpi.com
Dietary components exert protective effects against obesity and related metabolic and
cardiovascular disturbances by interfering with the molecular pathways leading to these …

Therapeutic potential of oleanolic acid in liver diseases

Y Wang, K Liu - Naunyn-Schmiedeberg's Archives of Pharmacology, 2024 - Springer
Liver-associated diseases affect millions of individuals worldwide. In developed countries,
the incidence of viral hepatitis is reducing due to advancements in disease prevention …

Chrysin Attenuates Fructose‐Induced Nonalcoholic Fatty Liver in Rats via Antioxidant and Anti‐Inflammatory Effects: The Role of Angiotensin‐Converting Enzyme 2 …

H Attia, N Albekairi, L Albdeirat… - Oxidative Medicine …, 2022 - Wiley Online Library
Aim. Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic
syndrome, and if untreated, it may propagate into end‐stage liver disease. The classical arm …

The effect and mechanism of oleanolic acid in the treatment of metabolic syndrome and related cardiovascular diseases

Q Luo, Y Wei, X Lv, W Chen, D Yang, Q Tuo - Molecules, 2024 - mdpi.com
Metabolic syndromes (MetS) and related cardiovascular diseases (CVDs) pose a serious
threat to human health. MetS are metabolic disorders characterized by obesity, dyslipidemia …

Long-term impact of neonatal intake of oleanolic acid on the expression of AMP-activated protein kinase, adiponectin and inflammatory cytokines in rats fed with a …

MG Matumba, AO Ayeleso, T Nyakudya, K Erlwanger… - Nutrients, 2019 - mdpi.com
AMP-activated protein kinase (AMPK) is known to regulate both glucose and lipid
metabolism, which play vital roles in the development of metabolic syndrome. One way of …