Abstract The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–
mediated responses in inflammation for more than a decade after it was first identified …

The oral mucosa is a primary barrier site and a portal for entry of microbes, food, and
airborne particles into the gastrointestinal tract. Nonetheless, mucosal immunity at this …

INTRODUCTION Studies of monogenic diseases have uncovered the importance of immune
pathways in human tissue-specific immunity and antimicrobial defense. In particular, human …

Abstract IL-17 (IL-17A) has emerged as a key mediator of protection against extracellular
microbes, but this cytokine also drives pathology in various autoimmune diseases …

The commensal fungus Candida albicans causes oropharyngeal candidiasis (OPC; thrush)
in settings of immunodeficiency. Although disseminated, vaginal, and oral candidiasis are all …

Our understanding of immunity to fungal pathogens has advanced considerably in recent
years. Particularly significant have been the parallel discoveries in the C-type lectin receptor …

Abstract T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the
effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the role of Th17 cells in …

Oropharyngeal candidiasis (OPC) is an opportunistic fungal infection caused by Candida
albicans. OPC is frequent in HIV/AIDS, implicating adaptive immunity. Mice are naive to …

For almost two decades, the Th1/Th2 paradigm has offered a productive conceptual
framework for investigating the pathogenesis of periodontitis. However, as with many other …

Fungal infections are becoming increasingly prevalent in the human population and
contribute to morbidity and mortality in healthy and immunocompromised individuals …