Members of the KCTD protein family play key roles in fundamental physio-pathological
processes including cancer, neurodevelopmental/neuropsychiatric, and genetic diseases …

The long-range communication between the two exosites of human α-thrombin (thrombin)
tightly modulates the protein-effector interactions. Duplex/quadruplex aptamers represent an …

The definition of the structural basis of protein thermostability represents a major topic in
structural biology and protein chemistry. We have recently observed that proteins isolated …

Abstract Thermotoga maritima Arginine Binding Protein has been extensively characterized
because of its peculiar features and its possible use as a biosensor. In this characterization …

Abstract Thermotoga maritima Arginine Binding Protein (TmArgBP) is a valuable candidate
for arginine biosensing in diagnostics. This protein is endowed with unusual structural …

The Ramachandran plot is a versatile and valuable tool that provides fundamental
information for protein structure determination, prediction, and validation. The structural …

The global/local fold of protein structures is stabilized by a variety of specific interactions. A
primary role in this context is played by hydrogen bonds. In order to identify novel motifs in …

Structural roles of loop regions are frequently overlooked in proteins. Nevertheless, they
may be key players in the definition of protein topology and in the self-assembly processes …

Spectroscopic studies carried out in the early seventies have shown that the β-homotetramer
of human hemoglobin (β 4-HbA) in the ferric state is a mixture of aquomet and bis-histidyl …

Substrate binding proteins represent a large protein family that plays fundamental roles in
selective transportation of metabolites across membrane. The function of these proteins …