The cardinal stages of macroautophagy are driven by core autophagy‐related (ATG)
proteins, whose ablation largely abolishes intracellular turnover. Disrupting ATG genes is …

Association of diabetes with an elevated risk of cardiac failure has been clinically evident.
Diabetes potentiates diastolic and systolic cardiac failure following the myocardial infarction …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Life and health span can be prolonged by calorie limitation or by pharmacologic agents that
mimic the effects of caloric restriction. Both starvation and the genetic inactivation of nutrient …

Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging
promotes the structural and functional declines of both the heart and the blood circulation …

Cardiovascular disease is the leading cause of death worldwide. As such, there is great
interest in identifying novel mechanisms that govern the cardiovascular response to disease …

Blood-brain barrier (BBB) disruption is a key event in triggering secondary damage to the
central nervous system (CNS) under stroke, and is frequently associated with abnormal …

Autophagy is a catabolic recycling pathway triggered by various intra-or extracellular stimuli
that is conserved from yeast to mammals. During autophagy, diverse cytosolic constituents …

Cardiovascular diseases are known to be the most fatal diseases worldwide.
Ischaemia/reperfusion (I/R) injury is at the centre of the pathology of the most common …

Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …