Glutamatergic dysfunction in Schizophrenia
AO Kruse, JR Bustillo - Translational Psychiatry, 2022 - nature.com
The NMDA-R hypofunction model of schizophrenia started with the clinical observation of
the precipitation of psychotic symptoms in patients with schizophrenia exposed to PCP or …
the precipitation of psychotic symptoms in patients with schizophrenia exposed to PCP or …
Functional MRS studies of GABA and glutamate/Glx–A systematic review and meta-analysis
Functional magnetic resonance spectroscopy (fMRS) can be used to investigate
neurometabolic responses to external stimuli in-vivo, but findings are inconsistent. We …
neurometabolic responses to external stimuli in-vivo, but findings are inconsistent. We …
Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls
There has been little analysis of neurochemical correlates of compulsive behaviour to
illuminate its underlying neural mechanisms. We use 7-Tesla proton magnetic resonance …
illuminate its underlying neural mechanisms. We use 7-Tesla proton magnetic resonance …
The trajectory of cortical GABA across the lifespan, an individual participant data meta-analysis of edited MRS studies
γ-Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the human brain
and can be measured with magnetic resonance spectroscopy (MRS). Conflicting accounts …
and can be measured with magnetic resonance spectroscopy (MRS). Conflicting accounts …
A review of machine learning applications for the proton MR spectroscopy workflow
DMJ van de Sande, JP Merkofer… - Magnetic …, 2023 - Wiley Online Library
This literature review presents a comprehensive overview of machine learning (ML)
applications in proton MR spectroscopy (MRS). As the use of ML techniques in MRS …
applications in proton MR spectroscopy (MRS). As the use of ML techniques in MRS …
Increased prefrontal GABA concentrations in adults with autism spectrum disorders
S Maier, AL Düppers, K Runge, M Dacko… - Autism …, 2022 - Wiley Online Library
The excitatory‐inhibitory imbalance hypothesis postulates dysregulation of the gamma‐
aminobutyric acid (GABA) and glutamate (Glu) neurotransmitter systems as a common …
aminobutyric acid (GABA) and glutamate (Glu) neurotransmitter systems as a common …
Does the change in glutamate to GABA ratio correlate with change in depression severity? A randomized, double-blind clinical trial
Previous proton magnetic resonance spectroscopy (1H-MRS) studies suggest a perturbation
in glutamate and/or GABA in Major Depressive Disorder (MDD). However, no studies …
in glutamate and/or GABA in Major Depressive Disorder (MDD). However, no studies …
Noninvasive 3-dimensional 1H-magnetic resonance spectroscopic imaging of human brain glucose and neurotransmitter metabolism using deuterium labeling at 3T …
Objectives Noninvasive, affordable, and reliable mapping of brain glucose metabolism is of
critical interest for clinical research and routine application as metabolic impairment is linked …
critical interest for clinical research and routine application as metabolic impairment is linked …
[HTML][HTML] Event-related functional magnetic resonance spectroscopy
Summary Proton-Magnetic Resonance Spectroscopy (MRS) is a non-invasive brain imaging
technique used to measure the concentration of different neurochemicals.“Single-voxel” …
technique used to measure the concentration of different neurochemicals.“Single-voxel” …
Anterior cingulate glutamate metabolites as a predictor of antipsychotic response in first episode psychosis: data from the STRATA collaboration
A Egerton, K Griffiths, C Casetta, B Deakin… - …, 2023 - nature.com
Elevated brain glutamate has been implicated in non-response to antipsychotic medication
in schizophrenia. Biomarkers that can accurately predict antipsychotic non-response from …
in schizophrenia. Biomarkers that can accurately predict antipsychotic non-response from …