It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …

Sepsis is involved in~ 20% of annual global deaths. Despite decades of research, the
current management of sepsis remains supportive rather than curative. Clinical trials in …

The classical model of the vital increase in systemic glucocorticoid availability in response to
sepsis-and hyperinflammation-induced critical illness is one of an activated hypothalamus …

Abstract Coronavirus Disease 19 (COVID-19) is associated with high morbidity and mortality
rates globally, representing the greatest health and economic challenge today. Several …

Sepsis, a dysregulated host response to infection characterized by organ failure, is one of
the leading causes of death worldwide. Disbalances of the immune response play an …

The cytokine tumor necrosis factor (TNF) plays important roles in limiting infection but is also
linked to sepsis. The mechanisms underlying these paradoxical roles are unclear. Here, we …

Sepsis is one of the medical conditions with a high mortality rate and lacks specific treatment
despite several years of extensive research. Bacterial extracellular vesicles (bEVs) are …

Abstract Objectives Glucocorticoids (GCs) are one of the most widely prescribed anti-
inflammatory drugs. By acting through their cognate receptor, the glucocorticoid receptor …

In sepsis, limited food intake and increased energy expenditure induce a starvation
response, which is compromised by a quick decline in the expression of hepatic PPARα, a …

The glucocorticoid receptor (GR) is a very versatile protein that comes in several forms,
interacts with many proteins and has multiple functions. Numerous therapies are based on …