Evolutionarily conserved across eukaryotic cells, macroautophagy (herein autophagy) is an
intracellular catabolic degradative process targeting damaged and superfluous cellular …

Simple Summary In the past few years, clinical as well as regular scientists have been
paying attention to medicinal applications of natural products. There are several …

mTOR, the mammalian target of rapamycin, integrates growth factor and nutrient signals to
promote a transformation from catabolic to anabolic metabolism, cell growth, and cell cycle …

Rapamycin and modified rapamycins (rapalogs) have been used to prevent allograft
rejection after organ transplant for over 15 years. The mechanistic target of rapamycin …

Combinatorial CRISPR-Cas screens have advanced the mapping of genetic interactions,
but their experimental scale limits the number of targetable gene combinations. Here, we …

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are RNA‐binding proteins associated
with complex and diverse biological processes such as processing of heterogeneous …

The mTOR pathway is a critical regulator of cell growth, proliferation, metabolism, and
survival. Dysregulation of mTOR signaling has been observed in most cancers and, thus, the …

Cancer cells consume glutamine, a nonessential amino acid (NEAA), at exceedingly high
rates to fulfill their energetic and biosynthetic requirements for proliferation. Glutamine plays …

During the fermentation of dark tea, theabrownins (TBs), carbohydrates, and other
substances get irreversibly complex. Recent research on the biological activity of TBs is not …

Rapamycin inhibits cell proliferation, yet preserves (re)-proliferative potential (RPP). RPP is
a potential of quiescent cells that is lost in senescent cells. mTOR drives conversion from …