Abstract The ClusPro server (https://cluspro. org) is a widely used tool for protein–protein
docking. The server provides a simple home page for basic use, requiring only two files in …

Like other HIV-1 auxiliary proteins, Vpr is conserved within all the human (HIV-1, HIV-2) and
simian (SIV) immunodeficiency viruses. However, Vpr and homologous HIV-2, and SIV Vpx …

The human immunodeficiency virus type 1 (HIV-1) Vpr protein is an attractive target for
antiretroviral drug development. The conservation both of the structure along virus evolution …

Exosomes are nano-sized vesicles produced by healthy and virus-infected cells. Exosomes
derived from infected cells have been shown to contain viral microRNAs (miRNAs). HIV-1 …

Vpr is a lentiviral accessory protein that is expressed late during the infection cycle and is
packaged in significant quantities into virus particles through a specific interaction with the …

Computational docking is a useful tool for predicting macromolecular complexes, which are
often difficult to determine experimentally. Here, we present the DOT2 software suite, an …

HIV-1 encodes four accesory proteins in addition to its structural and regulatory genes.
Uniquely amongst them, Vpr is abundantly present within virions, meaning it is poised to …

Sensing biomolecule interactions in living cells allows for a deeper understanding of the
mechanisms governing biological processes, and has increasing significance for …

The majority of T cells encountered by HIV-1 are non-activated and do not readily allow
productive infection. HIV-1 Vpr is highly abundant in progeny virions, and induces signalling …

Numerous studies published in the past two decades have identified the viral protein R (Vpr)
as one of the most versatile proteins in the life cycle of human immunodeficiency virus type 1 …