Cardiac ageing manifests as a decline in function leading to heart failure. At the cellular
level, ageing entails decreased replicative capacity and dysregulation of cellular processes …

Adult stem/progenitor are a small population of cells that reside in tissue-specific niches and
possess the potential to differentiate in all cell types of the organ in which they operate. Adult …

Diet is the only known intervention which has been conclusively shown to extend life span. It
can be argued the key role diet has to play in the aging process came to prominence as a …

Organoids are tiny, self-organized, three-dimensional tissue cultures that are derived from
the differentiation of stem cells. The growing interest in the use of organoids arises from their …

The topical administration of active compounds represents an advantageous strategy to
reach the various skin components as well as its appendages. Pilosebaceous follicles are …

Over the years strong evidence has been accumulated showing that aerobic physical
exercise exerts beneficial effects on the prevention and reduction of cardiovascular risk …

Cardiac remuscularization has been the stated goal of the field of regenerative cardiology
since its inception. Along with the refreshment of lost and dysfunctional cardiac muscle cells …

Background: Three-dimensional cell culture systems hold great promise for bridging the gap
between in vitro cell-based model systems and small animal models to study tissue biology …

Cardiovascular disease (CVD) remains the leading cause of death in Western countries.
Post-myocardial infarction heart failure can be considered a degenerative disease where …

Abstract miRNAs modulate cardiomyocyte specification by targeting mRNAs of cell cycle
regulators and acting in cardiac muscle lineage gene regulatory loops. It is unknown if or to …