The brain is vulnerable to excessive oxidative insults because of its abundant lipid content,
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …

Glutathione (GSH) is an important antioxidant found abundantly and synthesized
intracellularly in the cytosol in a tightly regulated fashion. It has diverse physiological …

Glioblastoma (GBM) is one of the most difficult cancers to effectively treat, in part because of
the lack of precision therapies and limited therapeutic access to intracranial tumor sites due …

Glioblastoma multiforme (GBM) is a neurologically debilitating disease that culminates in
death 14 to 16 months after diagnosis. An incomplete understanding of how cataloged …

Within the last few years, knowledge about vitamins has increased dramatically. This new
edition of a bestseller presents comprehensive summaries that analyze the chemical …

Murine models of atherosclerosis, such as the apolipoprotein E (apoE) or the LDL receptor
knockout mice, usually do not exhibit many of the cardinal features of human coronary heart …

Because cholesterol is a precursor for the synthesis of steroid hormones, steroidogenic
tissues have evolved multiple pathways to ensure adequate supplies of cholesterol. These …

Cholesterol is an essential component of both the peripheral nervous system and central
nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes …

Lipoproteins in plasma transport lipids between tissues, however, only high-density
lipoproteins (HDL) appear to traverse the blood–brain barrier (BBB); thus, lipoproteins found …

Molecules in biological systems often can perform more than one function. In particular,
many molecules have the ability to chemically scavenge free radicals and thus act in the test …