[HTML][HTML] CLIP and complementary methods
RNA molecules start assembling into ribonucleoprotein (RNP) complexes during
transcription. Dynamic RNP assembly, largely directed by cis-acting elements on the RNA …
transcription. Dynamic RNP assembly, largely directed by cis-acting elements on the RNA …
ALS genetics: gains, losses, and implications for future therapies
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by the loss
of motor neurons from the brain and spinal cord. The ALS community has made remarkable …
of motor neurons from the brain and spinal cord. The ALS community has made remarkable …
Postmortem cortex samples identify distinct molecular subtypes of ALS: retrotransposon activation, oxidative stress, and activated glia
OH Tam, NV Rozhkov, R Shaw, D Kim, I Hubbard… - Cell reports, 2019 - cell.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the progressive loss of motor neurons. While several pathogenic mutations have been …
the progressive loss of motor neurons. While several pathogenic mutations have been …
TEtranscripts: a package for including transposable elements in differential expression analysis of RNA-seq datasets
Y Jin, OH Tam, E Paniagua, M Hammell - Bioinformatics, 2015 - academic.oup.com
Motivation: Most RNA-seq data analysis software packages are not designed to handle the
complexities involved in properly apportioning short sequencing reads to highly repetitive …
complexities involved in properly apportioning short sequencing reads to highly repetitive …
Physiological functions and pathobiology of TDP‐43 and FUS/TLS proteins
The multiple roles played by RNA binding proteins in neurodegeneration have become
apparent following the discovery of TAR DNA binding protein 43 kDa (TDP‐43) and fused in …
apparent following the discovery of TAR DNA binding protein 43 kDa (TDP‐43) and fused in …
Tau activates transposable elements in Alzheimer's disease
Aging and neurodegenerative disease are characterized by genomic instability in neurons,
including aberrant activation and mobilization of transposable elements (TEs). Integrating …
including aberrant activation and mobilization of transposable elements (TEs). Integrating …
Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies
Transposable elements, known colloquially as 'jumping genes', constitute approximately
45% of the human genome. Cells utilize epigenetic defenses to limit transposable element …
45% of the human genome. Cells utilize epigenetic defenses to limit transposable element …
Mammalian transposable elements and their impacts on genome evolution
Transposable elements (TEs) are genetic elements with the ability to mobilize and replicate
themselves in a genome. Mammalian genomes are dominated by TEs, which can reach …
themselves in a genome. Mammalian genomes are dominated by TEs, which can reach …
Transposable element expression in tumors is associated with immune infiltration and increased antigenicity
Profound global loss of DNA methylation is a hallmark of many cancers. One potential
consequence of this is the reactivation of transposable elements (TEs) which could stimulate …
consequence of this is the reactivation of transposable elements (TEs) which could stimulate …
Human endogenous retrovirus-K contributes to motor neuron disease
The role of human endogenous retroviruses (HERVs) in disease pathogenesis is unclear.
We show that HERV-K is activated in a subpopulation of patients with sporadic amyotrophic …
We show that HERV-K is activated in a subpopulation of patients with sporadic amyotrophic …