Alzheimer's disease (AD) is conceptualized as a progressive consequence of two hallmark
pathological changes in grey matter: extracellular amyloid plaques and neurofibrillary …

Abstract Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) has continued
development and standardization of methodologies for biomarkers and has provided an …

Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive
impairment and affects all levels of the brain's vasculature. Features include diverse …

Objective: Examine how longitudinal cognitive trajectories relate to brain baseline measures
and change in lobar volumes in a racially/ethnically and cognitively diverse sample of older …

Objective: Alzheimer's disease and vascular dementia are responsible for more than 80% of
dementia cases. These two conditions share common risk factors including hypertension …

Alzheimer disease (AD) is the most common cause of dementia. Biological definitions of AD
are limited to the cerebral burden of amyloid β plaques, neurofibrillary pathology, and …

White matter hyperintensities (WMHs) are brain white matter lesions that are hyperintense
on fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) scans …

Background: The association of white matter hyperintensities (WMH) with age-related
vascular and neurodegenerative pathologies remains incompletely understood. Objective …

Abstract Introduction Cognitive decline in Alzheimer's disease is associated with amyloid
beta (Aβ) accumulation, neurodegeneration, and cerebral small vessel disease, but the …

Abstract Introduction White matter hyperintensities (WMHs) are common magnetic
resonance imaging (MRI) findings in the aging population in general, as well as in patients …