Continuous spermatogenesis in post-pubertal mammals is dependent on spermatogonial
stem cells (SSCs), which balance self-renewing divisions that maintain stem cell pool with …

Gametogenesis, the process of forming mature germ cells, is an integral part of both an
individual's and a species' health and well-being. This chapter focuses on critical male and …

Targeted protein degradation via small-molecule modulation of cereblon offers vast potential
for the development of new therapeutics. Cereblon-binding therapeutics carry the safety …

Interleukin-1 receptor associated kinase 4 (IRAK4) is an essential mediator of the IL-1R and
TLR signaling pathways, both of which have been implicated in multiple autoimmune …

Objective To determine the molecular characteristics of human spermatogonia and optimize
methods to enrich spermatogonial stem cells (SSCs). Design Laboratory study using human …

There is a growing body of evidence supporting that cancer cells share many similarities
with embryonic stem cells (ESCs). For example, aggressive cancers and ESCs share a …

Spermatogonial stem cell (SSC) transplantation has been shown to restore fertility in several
species and may have application for treating some cases of male infertility (eg, secondary …

Spermatogenesis is a multistep process that generates millions of spermatozoa per day in
mammals. A key to this process is the spermatogonial stem cell (SSC), which has the dual …

The spermatogenic lineage is established after birth when gonocytes migrate to the
basement membrane of seminiferous tubules and give rise to spermatogonial stem cells …

Mammalian spermatogenesis is a highly complex multi-step process sustained by a
population of mitotic germ cells with self-renewal potential known as spermatogonial stem …