The interaction over time of genetic, epigenetic and environmental factors (ie, autoimmune
ecology) increases or decreases the liability an individual would have to develop an …

Abstract Type I interferons (IFN-Is) are a very important group of cytokines that are produced
by innate immune cells but also act on adaptive immune cells. IFN-Is possess antiviral …

Pulmonary manifestations of systemic lupus erythematosus (SLE) are wide-ranging and
debilitating in nature. Previous studies suggest that anywhere between 20 and 90% of …

MicroRNAs (miRNAs) are evolutionally conserved, single-stranded RNAs that regulate gene
expression at the posttranscriptional level by disrupting translation. MiRNAs are key players …

Objective Patients with systemic lupus erythematosus (SLE) have increased mortality related
to cardiovascular disease (CVD). This systematic review and meta-analysis identified the …

Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects several
organs and causes variable clinical symptoms. Exploring new insights on genetic factors …

Objective Evobrutinib is a highly selective, orally administered Bruton's tyrosine kinase
(BTK) inhibitor. The objective of this phase II, multicenter, randomized, double‐blind …

Objective. To quantify healthcare utilization and costs by disease severity for patients with
systemic lupus erythematosus (SLE) in the United States. Methods. We conducted …

Objectives The aim was to explore patient experiences and views of their symptoms, delays
in diagnosis, misdiagnoses and medical support, to identify common experiences …

Objective To evaluate NKTR-358, a polyethylene glycol-interleukin-2 conjugate composition
designed to selectively induce regulatory T cells (Tregs), in first-in-human studies. Methods …