This review concentrates on advances in nitric oxide synthase (NOS) structure, function and
inhibition made in the last seven years, during which time substantial advances have been …

The endothelial nitric oxide synthase (eNOS), the expression of which is regulated by a
range of transcriptional and posttranscriptional mechanisms, generates nitric oxide (NO) in …

Nitric oxide (NO) is synthesised from l-arginine by the enzyme NO synthase (NOS). The
complex reaction involves the transfer of electrons from NADPH, via the flavins FAD and …

The nitric oxide (NO) synthase family of enzymes generate NO from l-arginine, which acts as
a biologic effector molecule in a broad number of settings. This report summarizes some of …

Endothelial cells situated at the interface between blood and the vessel wall play a crucial
role in controlling vascular tone and homeostasis, particularly in determining the expression …

Caveolae were originally identified as ffask-shaped invaginations of the plasma membrane
in endothelial and epithelial cells (14). Prior to the development of biochemical methods for …

Caveolin-1, the primary coat protein of caveolae, has been implicated as a regulator of
signal transduction through binding of its “scaffolding domain” to key signaling molecules …

Rather than being a constitutive enzyme as was first suggested, endothelial nitric oxide
synthase (eNOS) is dynamically regulated at the transcriptional, posttranscriptional, and …

Consistent with its classification as a Ca2+/calmodulin-dependent enzyme the constitutive
endothelial nitric oxide (NO) synthase (eNOS) can be activated by receptor-dependent and …

Renal function is highly dependent on endothelium-derived nitric oxide (NO). Several renal
disorders have been linked to impaired NO bioavailability. The enzyme that is responsible …