During sleep, animals do not eat, reproduce or forage. Sleeping animals are vulnerable to
predation. Yet, the persistence of sleep despite evolutionary pressures, and the deleterious …

A prominent idea emerging from the study of sleep is that this key behavioural state is
regulated in a complex fashion by ecologically and physiologically relevant environmental …

Many lines of evidence point to links between sleep regulation and energy homeostasis, but
mechanisms underlying these connections are unknown. During Caenorhabditis elegans …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder for which there is no
cure. Recently, several studies have reported a significant reduction in the incidence and …

Eukaryotic Tribbles proteins are pseudoenzymes that regulate multiple aspects of
intracellular signalling. Both Drosophila melanogaster and mammalian members of this …

The human 1q21. 1 deletion of ten genes is associated with increased risk of schizophrenia.
This deletion involves the β-subunit of the AMP-activated protein kinase (AMPK) complex, a …

Non-small cell lung cancer (NSCLC) is one of the main causes of death in the world. To
improve the diagnostic level and find new biological targets， GSE datasets were selected …

Sleep and circadian rhythms are observed broadly throughout animal phyla and influence
neural plasticity and cognitive function. However, the few phylogenetically conserved …

Consumption of foods that are high in fat contribute to obesity and metabolism‐related
disorders. Dietary lipids are comprised of triglycerides and fatty acids, and the highly …

Sleep and feeding are conserved behaviors across many taxa of the animal kingdom and
are essential for an organism's survival and fitness. Although Drosophila has been used to …