Investigations into the mixed muscle–secretory phenotype of cardiomyocytes from the atrial
appendages of the heart led to the discovery that these cells produce, in a regulated …

Insulin resistance (IR) is a pathological condition strongly associated with obesity. However,
corticosteroids or growth hormone therapy and genetic diseases may affect insulin …

Background: Heart failure (HF) with preserved ejection fraction (HFpEF) is a heterogeneous
syndrome. Phenotyping patients into pathophysiologically homogeneous groups may …

The ability of mammals to resist body fat accumulation is linked to their ability to expand the
number and activity of “brown adipocytes” within white fat depots. Activation of β-adrenergic …

B-type natriuretic peptide (BNP) is used widely to exclude heart failure (HF) in patients with
dyspnea. However, most studies of BNP have focused on diagnosing HF with reduced …

Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous entity with
complex pathophysiology and manifestations. Phenomapping is the process of applying …

The use of circulating biomarkers for heart failure (HF) is engrained in contemporary
cardiovascular practice and provides objective information about various pathophysiological …

This review examines the impact of obesity on cardiovascular health. We will review first,
relationship between obesity and hypertension. Second, we will describe obesity-related …

Natriuretic peptides (NPs) are a group of peptide-hormones mainly secreted from the heart,
signaling via c-GMP coupled receptors. NP are well known for their renal and cardiovascular …

Aim Epicardial adipose tissue (EAT) may play a role in the pathophysiology of heart failure
with preserved ejection fraction (HFpEF). We investigated associations of EAT with …