Streptococcus pyogenes is an important human pathogen that selectively interacts with
proteins involved in the humoral defense system, such as immunoglobulins and …

Group A streptococci (GAS, Streptococcus pyogenes) are exclusive human pathogens that
have been extensively studied for many decades. The spectrum of diseases caused by …

Most invasive bacterial infections are caused by species that more commonly colonize the
human host with minimal symptoms. Although phenotypic or genetic correlates underlying a …

In order to successfully colonize or invade a host, microorganisms need mechanisms to
escape recognition by the immune system or to modulate the responses directed against the …

Increased vascular permeability is a key feature of inflammatory conditions. In severe
infections, leakage of plasma from the vasculature induces a life-threatening hypotension …

Bacterial growth as a biofilm on solid surfaces is strongly associated with the development of
human infections. Biofilms on native heart valves (infective endocarditis) is a life-threatening …

Autophagy is reported to be an important innate immune defense against the intracellular
bacterial pathogen Group A Streptococcus (GAS). However, the GAS strains examined to …

Severe infections with Streptococcus pyogenes, an important human pathogen, are
associated with massive inflammatory reactions in the human host. Here we show that …

Several of the most significant bacterial pathogens in humans, including Streptococcus
pyogenes, express surface proteins that bind IgG antibodies via their fragment crystallizable …

Strategies for inhibiting phagolysosome fusion are essential for the intracellular survival and
replication of many pathogens. We found that the lysosomal synaptotagmin Syt VII is …