Neurotoxicity in acute and repeated organophosphate exposure

SX Naughton, AV Terry Jr - Toxicology, 2018 - Elsevier
The term organophosphate (OP) refers to a diverse group of chemicals that are found in
hundreds of products worldwide. As pesticides, their most common use, OPs are clearly …

Developmental neurotoxicity of the organophosphorus insecticide chlorpyrifos: from clinical findings to preclinical models and potential mechanisms

RD Burke, SW Todd, E Lumsden… - Journal of …, 2017 - Wiley Online Library
Organophosphorus (OP) insecticides are pest‐control agents heavily used worldwide.
Unfortunately, they are also well known for the toxic effects that they can trigger in humans …

Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment

DL Eaton, RB Daroff, H Autrup, J Bridges… - Critical reviews in …, 2008 - Taylor & Francis
This review examines the large body of toxicological and epidemiological information on
human exposures to chlorpyrifos, with an emphasis on the controversial potential for …

Current issues in organophosphate toxicology

LG Costa - Clinica chimica acta, 2006 - Elsevier
Organophosphates (OPs) are one of the main classes of insecticides, in use since the mid
1940s. OPs can exert significant adverse effects in non-target species including humans …

Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS study

AR Marks, K Harley, A Bradman, K Kogut… - Environmental …, 2010 - ehp.niehs.nih.gov
Background Exposure to organophosphate (OP) pesticides, well-known neurotoxicants, has
been associated with neurobehavioral deficits in children. Objectives We investigated …

Gene–environment interactions in developmental neurotoxicity: a case study of synergy between chlorpyrifos and CHD8 knockout in human brainspheres

S Modafferi, X Zhong, A Kleensang… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: Autism spectrum disorder (ASD) is a major public health concern caused by
complex genetic and environmental components. Mechanisms of gene–environment (G× E) …

Prenatal organophosphate pesticide exposure and traits related to autism spectrum disorders in a population living in proximity to agriculture

SK Sagiv, MH Harris, RB Gunier… - Environmental …, 2018 - ehp.niehs.nih.gov
Background: Prenatal exposure to organophosphate (OP) pesticides has been linked with
poorer neurodevelopment and behaviors related to autism spectrum disorders (ASD) in …

Assessment of developmental neurotoxicity induced by chemical mixtures using an adverse outcome pathway concept

F Pistollato, EM de Gyves, D Carpi, SK Bopp… - Environmental …, 2020 - Springer
Background In light of the vulnerability of the developing brain, mixture risk assessment
(MRA) for the evaluation of developmental neurotoxicity (DNT) should be implemented …

Developmental neurotoxicity testing in vitro: models for assessing chemical effects on neurite outgrowth

NM Radio, WR Mundy - Neurotoxicology, 2008 - Elsevier
In vitro models may be useful for the rapid toxicological screening of large numbers of
chemicals for their potential to produce toxicity. Such screening could facilitate prioritization …

In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities

BZ Schmidt, M Lehmann, S Gutbier, E Nembo… - Archives of …, 2017 - Springer
Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard
assessment. Since the interpretation of animal data and their extrapolation to man is …