1, 3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice

Y Fan, J Lu, J Liu, R Zhang, Z Yu, S Guan - Food and Chemical Toxicology, 2021 - Elsevier
Our study investigated the effects of food contaminant 1, 3-dichloro-2-propanol (1, 3-DCP)
on hepatic lipid metabolism and its mechanism. We found that triglyceride (TG), total …

Protective effects of allicin on 1, 3-DCP-induced lipid metabolism disorder in HepG2 cells

J Lu, B Fang, Z Meng, Y Zheng, X Tian… - Biomedicine & …, 2017 - Elsevier
Abstract Allicin (2-propene-1-sulfinothioic acid S-2-propenyl ester), with quite a good range
of hepatoprotective and antineoplastic properties, is a functional substance from garlic …

1, 3-dichloro-2-propanol induced lipid accumulation in HepG2 cells through cAMP/protein kinase A and AMP-activated protein kinase pathways via Gi/o-coupled …

J Lu, B Fang, Y Zheng, X Yu, G Huang, Z Wang… - Environmental …, 2017 - Elsevier
dichloro-2-propanol (1, 3-DCP) is a food born hepatoxic chloropropanol contaminant that
has been detected in a wide range of foods. In the present study, we investigated the effects …

[PDF][PDF] 基于血脂数据变化的实验性高脂血症动物模型制备

宋琪, 马于巽, 张艳贞, 陈文 - 中国公共卫生, 2020 - zgggws.com
目前, 血脂异常已发展为全球性公共卫生问题, 降脂活性物质的筛选及其作用机理研究受到广泛
关注, 而高脂血症模型制备是研究的前提. 本文针对膳食成分, 食品/环境污染因素 …

[PDF][PDF] Establishment of blood lipids variation-based experimental hyperlipidemia animal model: a review

Q SONG, Y MA, Y ZHANG - Chinese Journal of Public Health, 2020 - zgggws.com
Nowaday, the prevalence of dyslipidemia has developed into a global public health
problem. The screening of lipid-lowering active substances and the study of their …