Dynamic nuclear polarization for sensitivity enhancement in biomolecular solid-state NMR

T Biedenbänder, V Aladin, S Saeidpour… - Chemical …, 2022 - ACS Publications
Solid-state NMR with magic-angle spinning (MAS) is an important method in structural
biology. While NMR can provide invaluable information about local geometry on an atomic …

[HTML][HTML] Dynamic nuclear polarization for sensitivity enhancement in modern solid-state NMR

ASL Thankamony, JJ Wittmann, M Kaushik… - Progress in nuclear …, 2017 - Elsevier
The field of dynamic nuclear polarization has undergone tremendous developments and
diversification since its inception more than 6 decades ago. In this review we provide an in …

Highly efficient, water‐soluble polarizing agents for dynamic nuclear polarization at high frequency

C Sauvée, M Rosay, G Casano… - Angewandte Chemie …, 2013 - Wiley Online Library
Dynamic nuclear polarization coupled to solid-state NMR spectroscopy (DNP/ssNMR) is
emerging as a very powerful technique to overcome the limitations resulting from the …

Biomolecular and biological applications of solid-state NMR with dynamic nuclear polarization enhancement

WY Chow, G De Paëpe, S Hediger - Chemical Reviews, 2022 - ACS Publications
Solid-state NMR spectroscopy (ssNMR) with magic-angle spinning (MAS) enables the
investigation of biological systems within their native context, such as lipid membranes, viral …

Solid-state NMR studies of amyloid fibril structure

R Tycko - Annual review of physical chemistry, 2011 - annualreviews.org
Current interest in amyloid fibrils stems from their involvement in neurodegenerative and
other diseases and from their role as an alternative structural state for many peptides and …

Surface enhanced NMR spectroscopy by dynamic nuclear polarization

A Lesage, M Lelli, D Gajan, MA Caporini… - Journal of the …, 2010 - ACS Publications
It is shown that surface NMR spectra can be greatly enhanced using dynamic nuclear
polarization. Polarization is transferred from the protons of the solvent to the rare nuclei …

Direct observation of hierarchical protein dynamics

JR Lewandowski, ME Halse, M Blackledge, L Emsley - Science, 2015 - science.org
One of the fundamental challenges of physical biology is to understand the relationship
between protein dynamics and function. At physiological temperatures, functional motions …

High-resolution NMR studies of antibiotics in cellular membranes

J Medeiros-Silva, S Jekhmane, AL Paioni… - Nature …, 2018 - nature.com
The alarming rise of antimicrobial resistance requires antibiotics with unexploited
mechanisms. Ideal templates could be antibiotics that target the peptidoglycan precursor …

THz dynamic nuclear polarization NMR

EA Nanni, AB Barnes, RG Griffin… - IEEE Transactions on …, 2011 - ieeexplore.ieee.org
Dynamic nuclear polarization (DNP) increases the sensitivity of nuclear magnetic resonance
(NMR) spectroscopy by using high frequency microwaves to transfer the polarization of the …

Dynamic nuclear polarization of amyloidogenic peptide nanocrystals: GNNQQNY, a core segment of the yeast prion protein Sup35p

PCA van der Wel, KN Hu, J Lewandowski… - Journal of the …, 2006 - ACS Publications
Dynamic nuclear polarization (DNP) permits a∼ 102− 103 enhancement of the nuclear spin
polarization and therefore increases sensitivity in nuclear magnetic resonance (NMR) …