In the early 1980s, while using purified glycosyltransferases to probe glycan structures on
surfaces of living cells in the murine immune system, we discovered a novel form of …

Intermediate filaments (IFs) are cytoskeletal and nucleoskeletal structures that provide
mechanical and stress-coping resilience to cells, contribute to subcellular and tissue-specific …

Neurofilaments (NFs) are intermediate filaments with a diameter of 10 nm, similar to that of
neurons. Although they are present in perikarya and dendrites, neurofilaments are …

Alzheimer disease (AD) is the most common cause of dementia in adults. The current
therapy for AD has only moderate efficacy in controlling symptoms, and it does not cure the …

Glycosylation is one of the most common, and the most complex, forms of post‐translational
modification of proteins. This review serves to highlight the role of protein glycosylation in …

Alzheimer disease (AD) and related tauopathies are histopathologically characterized by a
specific type of slow and progressive neurodegeneration, which involves the abnormal …

It has been established for a long time that brain glucose metabolism is impaired in
Alzheimer's disease. Recent studies have demonstrated that impaired brain glucose …

Background Multiple pathophysiological processes have been described in Alzheimer's
disease (AD). Their inter-individual variations, complex interrelations, and relevance for …

Alzheimer disease (AD) is a growing problem for aging populations worldwide. Despite
significant efforts, no therapeutics are available that stop or slow progression of AD, which …

A paradigm-changing discovery in biology came about when it was found that nuclear and
cytosolic proteins could be dynamically glycosylated with a single O-linked β-N …