Antipsychotics-induced changes in synaptic architecture and functional connectivity: translational implications for treatment response and resistance
A de Bartolomeis, G De Simone, M Ciccarelli… - Biomedicines, 2022 - mdpi.com
Schizophrenia is a severe mental illness characterized by alterations in processes that
regulate both synaptic plasticity and functional connectivity between brain regions …
regulate both synaptic plasticity and functional connectivity between brain regions …
Schizophrenia and neurogenesis: a stem cell approach
A Iannitelli, A Quartini, P Tirassa, G Bersani - … & Biobehavioral Reviews, 2017 - Elsevier
Several recent research findings indicate that schizophrenia (SCZ) may begin with an
abnormal neuro-genesis from embryonic Neural Stem Cells (NSCs) and that this process …
abnormal neuro-genesis from embryonic Neural Stem Cells (NSCs) and that this process …
Alterations to the microbiota–colon–brain axis in high-fat-diet-induced obese mice compared to diet-resistant mice
Obesity is underpinned by both genetic and environmental factors, including a high-
saturated-fat diet. Some mice develop diet-induced obesity (DIO), but others remain diet …
saturated-fat diet. Some mice develop diet-induced obesity (DIO), but others remain diet …
Electrical stimulation with a conductive polymer promotes neurite outgrowth and synaptogenesis in primary cortical neurons in 3D
Deficits in neurite outgrowth and synaptogenesis have been recognized as an underlying
developmental aetiology of psychosis. Electrical stimulation promotes neuronal induction …
developmental aetiology of psychosis. Electrical stimulation promotes neuronal induction …
Inhibition of the schizophrenia-associated microRNA miR-137 disrupts Nrg1α neurodevelopmental signal transduction
KT Thomas, BR Anderson, N Shah, SE Zimmer… - Cell reports, 2017 - cell.com
Genomic studies have repeatedly associated variants in the gene encoding the microRNA
miR-137 with increased schizophrenia risk. Bioinformatic predictions suggest that miR-137 …
miR-137 with increased schizophrenia risk. Bioinformatic predictions suggest that miR-137 …
Effects of antipsychotic drugs on neurites relevant to schizophrenia treatment
XF Huang, X Song - Medicinal research reviews, 2019 - Wiley Online Library
Although antipsychotic drugs are mainly used for treating schizophrenia, they are widely
used for treating various psychiatric diseases in adults, the elderly, adolescents and even …
used for treating various psychiatric diseases in adults, the elderly, adolescents and even …
Schizophrenia risk candidate EGR3 is a novel transcriptional regulator of RELN and regulates neurite outgrowth via the Reelin signal pathway in vitro
F Nie, Q Zhang, J Ma, P Wang, R Gu… - Journal of …, 2021 - Wiley Online Library
Schizophrenia is a severe psychiatric disorder with a strong hereditary component that
affects approximately 1% of the world's population. The disease is most likely caused by the …
affects approximately 1% of the world's population. The disease is most likely caused by the …
Electrical stimulation using conductive polymer polypyrrole counters reduced neurite outgrowth of primary prefrontal cortical neurons from NRG1-KO and DISC1-LI …
Deficits in neurite outgrowth, possibly involving dysregulation of risk genes neuregulin-1
(NRG1) and disrupted in schizophrenia 1 (DISC1) have been implicated in psychiatric …
(NRG1) and disrupted in schizophrenia 1 (DISC1) have been implicated in psychiatric …
Olanzapine-induced endoplasmic reticulum stress and inflammation in the hypothalamus were inhibited by an ER stress inhibitor 4-phenylbutyrate
M He, XF Huang, G Gao, T Zhou, W Li, J Hu… - …, 2019 - Elsevier
Antipsychotics are the most important treatment for schizophrenia. However, antipsychotics,
particularly olanzapine and clozapine, are associated with severe weight gain/obesity side …
particularly olanzapine and clozapine, are associated with severe weight gain/obesity side …