Although weight gain is a serious but variable adverse effect of antipsychotics that has
genetic underpinnings, a comprehensive meta-analysis of pharmacogenetics of …

Almost fifty years after its first introduction into clinical care, clozapine remains the only
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …

Importance Previous evidence has implicated corticostriatal abnormalities in the
pathophysiology of psychosis. Although the striatum is the primary target of all efficacious …

The last decade of research into the pharmacogenetics of antipsychotics has seen the
development of genetic tests to determine the patients' metabolic status and the first attempts …

Importance of the field: Antipsychotic drug is the mainstay of treatment for schizophrenia,
and there are large inter-individual differences in clinical response and side effects …

Importance Limited evidence supports multigenetic pharmacogenomics–guided treatment
(MPGT) in schizophrenia. Objective To evaluate the clinical effectiveness of MPGT in …

Depression has become one of the most prevalent neuropsychiatric disorders characterized
by anhedonia, anxiety, pessimism, or even suicidal thoughts. Receptor theory has been …

Objective Several lines of evidence suggest that antipsychotic drug efficacy is mediated by
dopamine type 2 (D2) receptor blockade. Therefore, it seems plausible that variation in the …

Schizophrenia is a highly heritable, chronic, severe, disabling neurodevelopmental brain
disorder with a heterogeneous genetic and neurobiological background, which is still poorly …

By virtue of their large number, widespread distribution and important roles in cell
physiology and biochemistry, G-protein-coupled receptors (GPCR) play multiple important …