The alpha beta-hydrolase fold family of enzymes is rapidly becoming one of the largest
group of structurally related enzymes with diverse catalytic functions. Members in this family …

Enzymatic reactions are involved in most biological processes. Thus, there is a major
practical and fundamental interest in finding out what makes enzymes so efficient. Many …

Most enzymatic reactions have very large and remarkably similar apparent second-order
rate constants, kcat/KM, at mean values of about 107 M-1 s-1 with kcat in the range of 10 …

Halogenated organic compounds are produced industrially in large quantities and represent
an important class of environmental pollutants. However, an abundance of haloorganic …

This review considers the advances made in using computer simulations to elucidate the
catalytic power of enzymes. It is shown that some current approaches, and in particular the …

▪ Abstract Since the discovery of enzymes as biological catalysts, study of their enormous
catalytic power and exquisite specificity has been central to biochemistry. Nevertheless …

Reactions within enzyme-substrate (E ‚S) complexes share with intramolecular reactions the
close proximity of reactants. This proximity effect results in a much larger numerical value of …

Mechanistic insight into the biochemistry of carbon–halogen bond cleavage is rapidly
growing because of recent structural, biochemical and computational studies that have …

The hydrolytic haloalkane dehalogenases are promising bioremediation and biocatalytic
agents. Two general classes of dehalogenases have been reported from Xanthobacter and …

Publisher Summary This chapter focuses on the progress and the current state of
structure/function correlations of biomolecules. One of the primary goals of modern …