Learning from human responses to deconditioning environments: Improved understanding of the “use it or lose it” principle
DA Hart - Frontiers in Sports and Active Living, 2021 - frontiersin.org
Physical activity, mobility or patterned mobility (ie, exercise) is intrinsic to the functioning of
Homo sapiens, and required for maintenance of health. Thus, systems such as the …
Homo sapiens, and required for maintenance of health. Thus, systems such as the …
Musculoskeletal research in human space flight–unmet needs for the success of crewed deep space exploration
Abstract Based on the European Space Agency (ESA) Science in Space Environment
(SciSpacE) community White Paper “Human Physiology–Musculoskeletal system”, this …
(SciSpacE) community White Paper “Human Physiology–Musculoskeletal system”, this …
Genetic diversity modulates the physical and transcriptomic response of skeletal muscle to simulated microgravity in male mice
Developments in long-term space exploration necessitate advancements in
countermeasures against microgravity-induced skeletal muscle loss. Astronaut data shows …
countermeasures against microgravity-induced skeletal muscle loss. Astronaut data shows …
The role of mitochondria in mediation of skeletal muscle repair
Musculoskeletal health is directly linked to independence and longevity, but disease and
aging impairs muscle mass and health. Complete repair after a pathological or physiological …
aging impairs muscle mass and health. Complete repair after a pathological or physiological …
[HTML][HTML] A novel computational framework for the estimation of internal musculoskeletal loading and muscle adaptation in hypogravity
Introduction: Spaceflight is associated with substantial and variable musculoskeletal (MSK)
adaptations. Characterisation of muscle and joint loading profiles can provide key …
adaptations. Characterisation of muscle and joint loading profiles can provide key …
The effect of 60 days of 6° head-down-tilt bed rest on circulating adropin, irisin, retinol binding protein-4 (RBP4) and individual metabolic responses in young, healthy …
K Ward, E Mulder, P Frings-Meuthen… - Frontiers in …, 2024 - frontiersin.org
Background Alterations in the circulating concentrations and target-tissue action of
organokines underpin the development of insulin resistance in microgravity and gravity …
organokines underpin the development of insulin resistance in microgravity and gravity …
Optimal fibre length and maximum isometric force are the most influential parameters when modelling muscular adaptations to unloading using Hill-type muscle …
Introduction: Spaceflight is associated with severe muscular adaptations with substantial
inter-individual variability. A Hill-type muscle model is a common method to replicate muscle …
inter-individual variability. A Hill-type muscle model is a common method to replicate muscle …
The search for the ultimate exercise countermeasure to preserve crew health and ensure mission success in long‐duration spaceflight
R Fernandez‐Gonzalo, S Schneider… - Experimental …, 2025 - Wiley Online Library
The current understanding of crew health maintenance is founded upon decades of
physiological research conducted in terrestrial spaceflight analogues and in low Earth orbit …
physiological research conducted in terrestrial spaceflight analogues and in low Earth orbit …
[HTML][HTML] Relationship Between Muscle Tone and Elasticity: Simultaneous Quantitative Assessment Using Train-of-Four Monitoring and Continuous Shear Wave …
Background/Objectives: Non-invasive evaluations of muscle elasticity and tone are crucial in
musculoskeletal medicine. Shear wave elastography (SWE) provides quantitative …
musculoskeletal medicine. Shear wave elastography (SWE) provides quantitative …
[PDF][PDF] Evaluation of models used to assess effects and countermeasures of microgravity, with specific respect to their utility in simulating and/or predicting space …
JP Williams - 2023 - ntrs.nasa.gov
Within only a few years of Yuri Gagarin reaching low earth orbit (LEO) in 1961, it became
apparent that the biological stressors that are imposed on the human body during …
apparent that the biological stressors that are imposed on the human body during …