Viral carrier transport efficiency of gene delivery is high, depending on the type of vector.
However, viral delivery poses significant safety concerns such as inefficient/unpredictable …

The coronavirus disease 2019 (COVID-19) has spread worldwide and imposed a
substantial burden on human health, the environment, and socioeconomic development …

Intervertebral disc (IVD) degeneration is a major contributing factor to chronic low back pain
and disability, leading to imbalance between anabolic and catabolic processes, altered …

Colorectal carcinoma (CRC) poses heavy burden to human health and has an increasing
incidence. Currently, the existing biomarkers for CRC bring about restrained clinical …

Background: Intervertebral Disc (IVD) degeneration is a major public health concern, and
gene therapy seems a promising approach to delay or even reverse IVD degeneration …

The exact mechanisms of nucleic acid (NA) delivery with gene electrotransfer (GET) are still
unknown, which represents a limitation for its broader use. Further, not knowing the effects …

This study is the first to report the enhancement of cell migration and proliferation induced by
in vitro microsecond pulsed electric field (μsPEF) exposure of primary bovine annulus …

Intervertebral disc (IVD) degeneration (IDD) is the most universal pathogenesis of low back
pain (LBP), a prevalent and costly medical problem across the world. Persistent low back …

Gene delivery is the transfer of exogenous genetic material into somatic cells to modify their
gene expression, with applications including tissue engineering, regenerative medicine …

Plasmid DNA (pDNA) has been widely used for non-viral gene delivery. After pDNA
molecules enter a mammalian cell, they may be trapped in subcellular structures or …