5-Aminolevulinic acid (5-ALA) is a natural amino acid and a precursor of heme and
chlorophyll. Exogenously administered 5-ALA is metabolized into protoporphyrin IX (PpIX) …

After recent updates to the World Health Organization pathological criteria for diagnosing
and grading diffuse gliomas, all major North American and European neuro-oncology …

Glioblastoma multiforme (GBM) is the most malignant type of cerebral neoplasm in adults
with a poor prognosis. Currently, combination therapy with different anti‐cancer agents is at …

Management of patients with glioblastoma (GBM) is complex and involves implementing
standard therapies including resection, radiation therapy, and chemotherapy, as well as …

Simple Summary This study explores the use of fluorescence-guided resection in
glioblastoma surgery, focusing on the combined use of 5-aminolevulinic acid and sodium …

Background: Since its introduction in 2007 in Europe and in 2017 in the United States, 5-
ALA has demonstrated an undisputed advantage in providing real-time tumor visualization …

MGMT promoter methylation is related to the increased sensitivity of tumour tissue to
chemotherapy with temozolomide (TMZ) and thus to improved patient survival. However, it is …

Background Intraoperative photodynamic diagnosis (PDD) using 5-aminolevulinic acid (5-
ALA) is a widely adopted technique to enhance the extent of resection during high-grade …

Simple Summary We review recent advances in imaging techniques and applications of
artificial intelligence to improve the diagnosis and prognosis of high-grade gliomas, the …

Surgical resection is one of the most relevant practices in neurosurgery. Finding the correct
surgical extent of the tumor is a key question and so far several techniques have been …