Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
The molecular mechanism, targets, and novel molecules in the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurological illness that causes dementia mainly
in the elderly. The challenging obstacles related to AD has freaked global healthcare system …
in the elderly. The challenging obstacles related to AD has freaked global healthcare system …
Design, Synthesis, and Biological Evaluation of Piperazine and N-Benzylpiperidine Hybrids of 5-Phenyl-1,3,4-oxadiazol-2-thiol as Potential Multitargeted Ligands for …
Our present work demonstrates the successful design and synthesis of a new class of
compounds based upon a multitargeted directed ligand design approach to discover new …
compounds based upon a multitargeted directed ligand design approach to discover new …
Design and development of benzyl piperazine linked 5-phenyl-1, 2, 4-triazole-3-thione conjugates as potential agents to combat Alzheimer's disease
Our present work demonstrates the molecular hybridization-assisted design, synthesis, and
biological evaluation of 22 benzylpiperazine-linked 1, 2, 4-triazole compounds (PD1-22) as …
biological evaluation of 22 benzylpiperazine-linked 1, 2, 4-triazole compounds (PD1-22) as …
Intranasally co-administered berberine and curcumin loaded in transfersomal vesicles improved inhibition of amyloid formation and BACE-1
Selective permeability of the blood–brain barrier restricts the treatment efficacy of neurologic
diseases. Berberine (BBR) and curcumin (CUR)-loaded transferosomes (TRANS) were …
diseases. Berberine (BBR) and curcumin (CUR)-loaded transferosomes (TRANS) were …
Design, synthesis, biological evaluation, and docking study of novel dual-acting thiazole-pyridiniums inhibiting acetylcholinesterase and β-amyloid aggregation for …
New compounds containing thiazole and pyridinium moieties were designed and
synthesized. The potency of the synthesized compounds as selective inhibitors of …
synthesized. The potency of the synthesized compounds as selective inhibitors of …
The recent development of donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's agents: highlights from 2010 to 2020
RT Kareem, F Abedinifar, EA Mahmood, AG Ebadi… - RSC …, 2021 - pubs.rsc.org
Dementia is a term used to define different brain disorders that affect memory, thinking,
behavior, and emotion. Alzheimer's disease (AD) is the second cause of dementia that is …
behavior, and emotion. Alzheimer's disease (AD) is the second cause of dementia that is …
Design and development of molecular hybrids of 2-pyridylpiperazine and 5-phenyl-1, 3, 4-oxadiazoles as potential multifunctional agents to treat Alzheimer's disease
The diverse nature of Alzheimer's disease (AD) has prompted researchers to develop multi-
functional agents. Herein, we have designed and synthesized molecular hybrids of 2 …
functional agents. Herein, we have designed and synthesized molecular hybrids of 2 …
Molecular hybridization: a powerful tool for multitarget drug discovery
P de Sena Murteira Pinheiro, LS Franco… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction The current drug discovery paradigm of 'one drug, multiple targets' has gained
attention from both the academic medicinal chemistry community and the pharmaceutical …
attention from both the academic medicinal chemistry community and the pharmaceutical …
Effects of disulfide bonds on binding of inhibitors to β-amyloid cleaving enzyme 1 decoded by multiple replica accelerated molecular dynamics simulations
J Chen, B Yin, W Wang, H Sun - ACS Chemical Neuroscience, 2020 - ACS Publications
The β-amyloid cleaving enzyme 1 (BACE1) has been thought to be an efficient target for
treatment of Alzheimer's disease (AD). Deep insight into inhibitor–BACE1 binding …
treatment of Alzheimer's disease (AD). Deep insight into inhibitor–BACE1 binding …