Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental
cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with …

The Wnt signaling pathway is critically involved in both the development and homeostasis of
tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been …

Many potential targets for CAR-T cells in solid tumors are expressed in some normal tissues,
raising concern for off-tumor toxicity. Following lymphodepletion, CAR-T cells targeting the …

Since its initial identification in 1992 as a possible class 1 cell-surface receptor without a
known parent ligand, receptor tyrosine kinase–like orphan receptor 1 (ROR1) has stimulated …

The overall efficacy of chimeric antigen receptor modified T cells (CARTs) remain limited in
solid tumors despite intensive studies that aim at targeting multiple antigens, enhancing …

The WNT pathway is one of the major signaling cascades frequently deregulated in human
cancer. While research had initially focused on signal transduction centered on β-catenin as …

Background Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncofetal protein
present on many cancers. Zilovertamab vedotin (ZV) is an antibody–drug conjugate …

Purpose: This study examines cell surface ROR1 expression in human tumors and normal
tissues. ROR1 is considered a promising target for cancer therapy due to putative tumor …

Cirmtuzumab is a humanized monoclonal antibody (mAb) that targets ROR1, an
oncoembryonic orphan receptor for Wnt5a found on cancer stem cells (CSCs). Aberrant …

Richter syndrome (RS) represents the transformation of chronic lymphocytic leukemia (CLL),
typically to an aggressive lymphoma. Treatment options for RS are limited and the disease is …