Dementia is a leading cause of disability and death worldwide. At present there is no
disease modifying treatment for any of the most common types of dementia such as …

The brain is the central and most complex organ in the nervous system, comprising billions
of neurons that constantly communicate through trillions of connections called synapses …

Glial activation and inflammation coincide with neurofibrillary tangle (NFT) formation in
neurons. However, the mechanism behind the interaction between tau fibrils and glia is …

Objective Synaptic loss is an early feature of neurodegenerative disease models, and is
severe in post mortem clinical studies, including frontotemporal dementia. Positron emission …

Next to amyloid and tau, synaptic loss is a key pathological hallmark in Alzheimer's disease,
closely related to cognitive dysfunction and neurodegeneration. Tau is thought to cause …

The risk for neurodegenerative diseases increases with aging, with various pathological
conditions and functional deficits accompanying these diseases. We have previously …

Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by four-
repeat tau deposition in various cell types and anatomical regions, and can manifest as …

Atypical parkinsonisms (APs) are a group of diseases linked to tau pathology. These include
progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). In the initial …

The development of novel PET imaging agents that selectively bind specific dementia-
related targets can contribute significantly to accurate, differential and early diagnosis of …

With the emergence of positron emission tomography (PET) in the late 1970s, psychiatry
had access to a tool capable of non‐invasive assessment of human brain function. Early …