Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation
Z Nagy, L Tora - Oncogene, 2007 - nature.com
Transcription in eukaryotes is a tightly regulated, multistep process. Gene-specific
transcriptional activators, several different co-activators and general transcription factors are …
transcriptional activators, several different co-activators and general transcription factors are …
Transcription-associated histone modifications and cryptic transcription
M Smolle, JL Workman - Biochimica et Biophysica Acta (BBA)-Gene …, 2013 - Elsevier
Eukaryotic genomes are packaged into chromatin, a highly organized structure consisting of
DNA and histone proteins. All nuclear processes take place in the context of chromatin …
DNA and histone proteins. All nuclear processes take place in the context of chromatin …
CBP/p300-mediated acetylation of histone H3 on lysine 56
Acetylation within the globular core domain of histone H3 on lysine 56 (H3K56) has recently
been shown to have a critical role in packaging DNA into chromatin following DNA …
been shown to have a critical role in packaging DNA into chromatin following DNA …
Multiple faces of the SAGA complex
The SAGA complex provides a paradigm for multisubunit histone modifying complexes.
Although first characterized as a histone acetyltransferase, because of the Gcn5 subunit …
Although first characterized as a histone acetyltransferase, because of the Gcn5 subunit …
CBP and Gcn5 drive zygotic genome activation independently of their catalytic activity
Zygotic genome activation (ZGA) is a crucial step of embryonic development. So far, little is
known about the role of chromatin factors during this process. Here, we used an in vivo RNA …
known about the role of chromatin factors during this process. Here, we used an in vivo RNA …
Histone modifiers in cancer: friends or foes?
Covalent modifications of histones can regulate all DNA-dependent processes. In the last
few years, it has become more and more evident that histone modifications are key players …
few years, it has become more and more evident that histone modifications are key players …
[HTML][HTML] Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein
Eukaryotic GCN5 acetyltransferases influence diverse biological processes by acetylating
histones and non-histone proteins and regulating chromatin and gene-specific transcription …
histones and non-histone proteins and regulating chromatin and gene-specific transcription …
ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding
The Ada2a-containing (ATAC) complex is an essential Drosophila melanogaster histone
acetyltransferase (HAT) complex that contains the transcriptional cofactors Gcn5 (KAT2) …
acetyltransferase (HAT) complex that contains the transcriptional cofactors Gcn5 (KAT2) …
The GCN5: its biological functions and therapeutic potentials
General control non-depressible 5 (GCN5) or lysine acetyltransferase 2A (KAT2A) is one of
the most highly studied histone acetyltransferases. It acts as both histone acetyltransferase …
the most highly studied histone acetyltransferases. It acts as both histone acetyltransferase …
Glial sphingosine-mediated epigenetic regulation stabilizes synaptic function in Drosophila models of Alzheimer's disease
Destabilization of neural activity caused by failures of homeostatic regulation has been
hypothesized to drive the progression of Alzheimer's Disease (AD). However, the …
hypothesized to drive the progression of Alzheimer's Disease (AD). However, the …