Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

DNA methylation is an essential epigenetic modification for mammalian development and is
crucial for the establishment and maintenance of cellular identity. Traditionally, DNA …

Gastric cancer is one of the most common types of cancer and the second most common
cause of cancer-related mortality worldwide. An increasing number of recent studies have …

Background: The farnesoid X receptor (FXR) regulates bile acid (BA) metabolism and
possesses tumor suppressor functions. FXR expression is reduced in colorectal tumors of …

Background Little is known about whether UVB can directly influence epigenetic regulatory
pathways to induce cutaneous squamous cell carcinoma (CSCC). This study aimed to …

The intestinal epithelium forms the inner layer of the human intestine and serves a wide
range of diverse functions. Its constant exposure to a vast amount of complex microbiota …

The intestinal tract is the entry gate for nutrients and symbiotic organisms, being in constant
contact with external environment. DNA methylation is one of the keys to how environmental …

Colorectal cancer initiation and progression result from the accumulation of genetic and
epigenetic alterations. Although aberrant gene expression and DNA methylation profiles are …

The degree of histologic cellular differentiation of a cancer has been associated with
prognosis but is subjectively assessed. We hypothesized that information about tumor …

DNA methylation, an epigenetic control mechanism in mammals, is widely present in the
intestinal tract during the differentiation and proliferation of epithelial cells. Cells in stem cell …