Despite considerable advances in microsurgical techniques over the past decades, bone
tissue remains a challenging arena to obtain a satisfying functional and structural restoration …

Alginate is an excellent biodegradable and renewable material that is already used for a
broad range of industrial applications, including advanced fields, such as biomedicine and …

Three-dimensional (3D) bioprinting is an appealing approach for building tissues; however,
bioprinting of mini-tissue blocks (ie, spheroids) with precise control on their positioning in 3D …

Stem cells (SCs) hold great promise for cell therapy, tissue engineering, and regenerative
medicine as well as pharmaceutical and biotechnological applications. They have the …

This review compiles information regarding the use of alginate, and in particular alginate
hydrogels, in culturing cells in 3D. Knowledge of alginate chemical structure and …

Bulk matrix stiffness has emerged as a key mechanical cue in stem cell differentiation. Here,
we show that the commitment and differentiation of human mesenchymal stem cells …

As one of the major challenges in the field of tissue engineering, large skeletal defects have
attracted wide attention from researchers. Collagen (Col) and hydroxyapatite (HA), the most …

Genotypic and phenotypic alterations in the bone marrow (BM) microenvironment, in
particular in osteoprogenitor cells, have been shown to support leukemogenesis. However …

In this study, bone scaffolds composed of polycaprolactone (PCL), piezoelectric poly (3-
hydroxybutyrate-co-3-hydroxyvalerate)(PHBV) and a combination of poly (3-hydroxybutyrate …

Mesenchymal stem cells (MSCs) are self-renewing multipotent cells that have the capacity to
secrete multiple biologic factors that can restore and repair injured tissues. Preclinical and …