Gastrointestinal-based drug delivery is considered the preferred mode of drug
administration owing to its convenience for patients, which improves adherence. However …

Colon-targeted oral delivery of drugs remains as an appealing and promising approach for
the treatment of prevalent intestinal diseases (ID), such as inflammatory bowel disease (IBD) …

Site-specific colon drug delivery is a practical approach for the treatment of local diseases of
the colon with several advantages such as rapid onset of action and reduction of the dosage …

Most patients with ulcerative colitis (UC) have mild-to-moderate disease activity, with low risk
of colectomy, and are managed by primary care physicians or gastroenterologists. Optimal …

Intestinal epithelial cells are covered by the brush border, which consists of densely packed
microvilli. The Intermicrovillar Adhesion Complex (IMAC) links the microvilli and is required …

Background & Aims We evaluated the efficacy of herbal combination of curcumin-QingDai
(CurQD) in active ulcerative colitis (UC). Methods Part I was an open-label trial of CurQD in …

Abstract Background and Aims The gut microbiota plays an important role in the
metabolization and modulation of several types of drugs. With this study we aimed to review …

The pathogenesis of ulcerative colitis (UC) is complicated with impaired intestinal epithelial
barrier and imbalanced gut microbiota. Both selenium and probiotics have shown effects in …

Objectives Drug product performance in patients with gastrointestinal (GI) diseases can be
altered compared to healthy subjects due to pathophysiological changes. In this review …

The current study aimed at developing and optimizing a prompt, simple and efficient RP-
UHPLC method based on Quality by Design (QbD) for analyzing mesalamine. Experimental …