Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm driven by BCR-
ABL1 oncoprotein, which plays a pivotal role in CML pathology, diagnosis, and treatment as …

Cancer immunotherapy, a promising and widely applied mode of oncotherapy, makes use of
immune stimulants and modulators to overcome the immune dysregulation present in …

Acute myeloid leukemia (AML) kills 75% of patients and represents a major clinical
challenge with a need to improve on current treatment approaches. Targeting sphingosine …

Exosomes are small membrane vesicles of endocytic origin that are produced by both tumor
and normal cells and can be found in physiological fluids like plasma and cell culture …

Abstract Purpose of Review Tyrosine kinase inhibitors (TKIs) are very successful for the
treatment of chronic myeloid leukaemia (CML) but are not curative in most patients due to …

Chronic myeloid leukemia (CML) is a classical example of stem cell cancer since it arises in
a multipotent hematopoietic stem cell upon the acquisition of the t (9; 22) chromosomal …

Exosomes are small membrane vesicles of endocytic origin containing cytokines, RNAs,
growth factors, proteins, lipids, and metabolites. They have been identified as fundamental …

The therapeutic landscape for chronic myeloid leukemia (CML) has improved significantly
with the approval of tyrosine kinase inhibitors (TKIs) for therapeutic use. Most patients with …

Cancer stem cells (CSCs) are self-renewing multipotent cells that play a vital role in the
development of cancer drug resistance conditions. Various therapies like conventional …

Background and purpose The reciprocal translocation of the ABL gene from chromosome 9
to chromosome 22 near the BCR gene gives rise to chronic myelogenous leukemia (CML) …