Proteins and peptides have played a pivotal role in revolutionizing disease treatment over
the last century. Despite their commercial success, protein therapeutics can be eliminated or …

While the intensity of vibrational circular dichroism (VCD) signals is commonly 104–105
times smaller than that of corresponding IR signals, several kinds of systems display …

Amyloid fibrils of proteins such as α-synuclein are a hallmark of neurodegenerative diseases
and much research has focused on their kinetics and mechanisms of formation. The …

Peptide-based drug discovery has surged with the development of peptide hormone-derived
analogs for the treatment of diabetes and obesity. Machine learning (ML)-enabled …

While GLP-1 and its analogues are important pharmaceutical agents in the treatment of type
2 diabetes and obesity, their susceptibility to aggregate into amyloid fibrils poses a …

Aggregation of peptide molecules into amyloid fibrils is a characteristic feature of several
degenerative diseases. However, the details behind amyloid-formation, and other self …

L'islet amyloid polypeptide (IAPP), également connu sous le nom d'amyline ou peptide
associé au diabète, a été initialement observé par Eugène Opie en 1901 au niveau de …

Working with fibrillation prone peptides is an adventure, to say the least, but harnessing their
therapeutic potential is a challenge worth facing. On comparison to small molecules …