Isoxazole, constituting an important family of five-membered heterocycles with one oxygen
atom and one nitrogen atom at adjacent positions is of immense importance because of its …

Mosquito-borne diseases (including malaria) belong among the leading causes of death in
humans. Vector control is a crucial part of the global strategy for management of mosquito …

Malaria is a devastating disease in sub-Saharan Africa, and current vector control measures
are threatened by emerging resistance mechanisms. With the goal of developing new …

A Sc (OTf) 3-catalyzed iodocyclization/Ritter-type amidation of N-alkoxypropiolamides for the
synthesis of 4-iodoisoxazol-3 (2 H)-ones bearing an amide group has been developed. This …

Insecticide resistance jeopardizes the prevention of infectious diseases such as malaria and
dengue fever by vector control of disease-transmitting mosquitoes. Effective new insecticidal …

Vector control of disease-transmitting mosquitoes is increasingly important due to the re-
emergence and spread of infections such as malaria and dengue. We have conducted a …

Resistance development in insects significantly threatens the important benefits obtained by
insecticide usage in vector control of disease-transmitting insects. Discovery of new …

Hymexazol is an efficient and low-toxicity soil fungicide. In this work, a fully continuous flow
process for the synthesis of hymexazol has been developed. This process begins with …

Great reductions in malaria mortality have been accomplished in the last 15 years, in part
due to the widespread roll-out of insecticide-treated bednets across sub-Saharan Africa. To …

A library of novel sulfoximine-isoxazole hybrids was synthesized and evaluated for
antimalarial activity. The subsequential synthetic pathways, which included the alkylation of …