▪ Abstract Pseudogenes have been defined as nonfunctional sequences of genomic DNA
originally derived from functional genes. It is therefore assumed that all pseudogene …

The bursa of Fabricius is critical for the normal development of B lymphocytes in birds. It is
productively colonized during embryonic life by a limited number of B cell precursors that …

Three processes alter genomic sequence and structure at the immunoglobulin genes of B
lymphocytes: gene conversion, somatic hypermutation, and class switch recombination …

The variable lymphocyte receptors (VLRs) of jawless vertebrates such as lamprey and
hagfish are composed of highly diverse modular leucine-rich repeats. Each lymphocyte …

▪ Abstract This review addresses issues related to the evolution of the complex multigene
families of antigen binding receptors that function in adaptive immunity. Advances in …

The vertebrate B-cell repertoire is capable of generating up to 10 (9) different antibody
molecules using relatively few germline immunoglobulin (Ig) gene segments. To generate …

Rabbits preferentially utilize only one of their multiple functional germline immunoglobulin
VH genes. This preferential usage of one gene, VH7, miser, the question of how rabbits …

The yeast HPR1 gene plays an important role in genome stability, as indicated by the
observation that hpr1 mutants have high frequencies of DNA repeat recombination and …

We have identified two novel yeast genes, THO1 and THO2, that partially suppress the
transcription defects of hpr1Δ mutants by overexpression. We show by in vivo transcriptional …

Sažetak Chickens, as a source of desired antibodies, represent an alternate animal system
that offers some advantages with respect to animal care, high productivity and special …