Platelet extracellular vesicles: beyond the blood

F Puhm, E Boilard, KR Machlus - Arteriosclerosis, thrombosis, and …, 2021 - Am Heart Assoc
Extracellular vesicles (EVs) are a means of cell-to-cell communication and can facilitate the
exchange of a broad array of molecules between adjacent or distant cells. Platelets are …

Platelets and extracellular vesicles and their cross talk with cancer

S Lazar, LE Goldfinger - Blood, The Journal of the American …, 2021 - ashpublications.org
Platelets play significant and varied roles in cancer progression, as detailed throughout this
review series, via direct interactions with cancer cells and by long-range indirect interactions …

Platelet‐rich plasma‐derived extracellular vesicles: A superior alternative in regenerative medicine?

J Wu, Y Piao, Q Liu, X Yang - Cell Proliferation, 2021 - Wiley Online Library
Abstract Platelet‐rich plasma (PRP), due to its promising therapeutic properties, has been
used in regenerative medicine for more than 30 years and numerous encouraging outcomes …

Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p

M Qu, X Zou, F Fang, S Wang, L Xu, Q Zeng… - Nature …, 2020 - nature.com
Thrombosis leads to platelet activation and subsequent degradation; therefore,
replenishment of platelets from hematopoietic stem/progenitor cells (HSPCs) is needed to …

Platelet cancer cell interplay as a new therapeutic target

K Morris, B Schnoor, AL Papa - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
The interaction between circulating tumor cells and platelets is a key factor in cancer
metastasis. These interactions, driven by a variety of receptors, support circulating tumor …

[HTML][HTML] Exchange of cellular components between platelets and tumor cells: impact on tumor cells behavior

A Rodriguez-Martinez, I Simon-Saez, S Perales… - Theranostics, 2022 - ncbi.nlm.nih.gov
Background: Platelets are active players in tumorigenesis, although the exact interactive
mechanisms and their direct impact on tumor cells remain largely unknown. Methods …

microRNAs orchestrate pathophysiology of breast cancer brain metastasis: advances in therapy

RK Kanchan, JA Siddiqui, S Mahapatra, SK Batra… - Molecular cancer, 2020 - Springer
Brain metastasis (BM) predominantly occurs in triple-negative (TN) and epidermal growth
factor 2 (HER2)-positive breast cancer (BC) patients, and currently, there is an unmet need …

The role of microvesicles and its active molecules in regulating cellular biology

YM Lv, J Tan, Y Miao, Q Zhang - Journal of Cellular and …, 2019 - Wiley Online Library
Cell‐derived microvesicles are membrane vesicles produced by the outward budding of the
plasma membrane and released by almost all types of cells. These have been considered …

Platelets extracellular vesicles as regulators of cancer progression—an updated perspective

M Żmigrodzka, O Witkowska-Piłaszewicz… - International journal of …, 2020 - mdpi.com
Extracellular vesicles (EVs) are a diverse group of membrane-bound structures secreted in
physiological and pathological conditions by prokaryotic and eukaryotic cells. Their role in …

Noncoding RNAs in tumor metastasis: molecular and clinical perspectives

QL Liu, Z Zhang, X Wei, ZG Zhou - Cellular and Molecular Life Sciences, 2021 - Springer
Metastasis is the main culprit of cancer-associated mortality and involves a complex and
multistage process termed the metastatic cascade, which requires tumor cells to detach from …