QT prolongation, torsades de pointes, and psychotropic medications: a 5-year update

SR Beach, CM Celano, AM Sugrue, C Adams… - Psychosomatics, 2018 - Elsevier
Background Some psychotropic medications have been associated with prolongation of the
QT interval and QT prolongation, especially in those with medical illness, and are linked to …

Anterior capsulotomy for obsessive-compulsive disorder: a review of old and new literature

J Pepper, L Zrinzo, M Hariz - Journal of Neurosurgery, 2019 - thejns.org
Over the last two decades, deep brain stimulation (DBS) has gained popularity as a
treatment of severe and medically refractory obsessive-compulsive disorder (OCD), often …

N-acetylcysteine prevents olanzapine-induced oxidative stress in mHypoA-59 hypothalamic neurons

Z Boz, M Hu, Y Yu, XF Huang - Scientific Reports, 2020 - nature.com
Olanzapine is a second-generation antipsychotic (AP) drug commonly prescribed for the
treatment of schizophrenia. Recently, olanzapine has been found to cause brain tissue …

Drug-specific risk of severe QT prolongation following acute drug overdose

SL Campleman, J Brent, AF Pizon, J Shulman… - Clinical …, 2020 - Taylor & Francis
Abstract Background: Severe QT prolongation (SQTP) has been identified as a strong
predictor of adverse cardiovascular events in acute drug overdose, but drug-specific causes …

Olanzapine-induced nonalcoholic fatty liver disease: the effects of differential food pattern and the involvement of PGRMC1 signaling

ZY Zhu, T Cao, H Chen, BK Zhang, CQ Lin… - Food and Chemical …, 2023 - Elsevier
Detrimental dietary habits with high-fat food are common in the psychiatric population,
leading to higher obesity rate. Olanzapine (OLZ), as one of the mainstream antipsychotic …

High-dose olanzapine in treatment-resistant schizophrenia: a systematic review

L Gannon, J Reynolds, M Mahon… - Therapeutic …, 2023 - journals.sagepub.com
Background: Treatment-resistant schizophrenia (TRS) affects approximately 30% of people
with schizophrenia. Clozapine is the gold standard treatment for TRS but is not always …

Prevalence and solving strategies of drug-related problems in adult psychiatric inpatients-a systematic review

K Wien, P Reißner, G Hefner, J Thern… - Frontiers in …, 2024 - frontiersin.org
Introduction Most psychiatric inpatients receive psychopharmacological treatment indicated
for their mental diseases. The aim of this systematic review is to give clinical pharmacists …

[HTML][HTML] Combination of olanzapine and samidorphan has no clinically relevant effects on ECG parameters, including the QTc interval: results from a phase 1 QT/QTc …

L Sun, S Yagoda, H Xue, R Brown, N Nangia… - Progress in Neuro …, 2020 - Elsevier
Background OLZ/SAM is a combination of olanzapine, an atypical antipsychotic, and
samidorphan, an opioid antagonist, and is in development for the treatment of schizophrenia …

Harmonizing post-market surveillance of prescription drug misuse: a systematic review of observational studies using routinely collected data (2000–2013)

B Blanch, NA Buckley, L Mellish, AH Dawson… - Drug safety, 2015 - Springer
Background Prescription drug misuse is a growing public health concern globally. Routinely
collected data provide a valuable tool for quantifying prescription drug misuse. Objective To …

Long-term mortality after poisoning with antipsychotics

S Toft, H Horwitz, KP Dalhoff - Clinical toxicology, 2017 - Taylor & Francis
Introduction: The objective of this study was to investigate the long-term mortality and cause
of death after deliberate self-poisoning with antipsychotics. Furthermore, we investigated the …