Self-assembling nucleic acid nanostructures functionalized with aptamers

A Krissanaprasit, CM Key, S Pontula… - Chemical …, 2021 - ACS Publications
Researchers have worked for many decades to master the rules of biomolecular design that
would allow artificial biopolymer complexes to self-assemble and function similarly to the …

DNA nanostructure-based nucleic acid probes: construction and biological applications

DX Wang, J Wang, YX Wang, YC Du, Y Huang… - Chemical …, 2021 - pubs.rsc.org
In recent years, DNA has been widely noted as a kind of material that can be used to
construct building blocks for biosensing, in vivo imaging, drug development, and disease …

A tetrahedral framework DNA‐based bioswitchable miRNA inhibitor delivery system: application to skin anti‐aging

S Li, Y Liu, T Zhang, S Lin, S Shi, J He, Y Xie… - Advanced …, 2022 - Wiley Online Library
MicroRNA (miR)‐based therapy shows strong potential; however, structural limitations pose
a challenge in fully exploiting its biomedical functionality. Tetrahedral framework DNA (tFNA) …

Functional DNA–polymer conjugates

CJ Whitfield, M Zhang, P Winterwerber, Y Wu… - Chemical …, 2021 - ACS Publications
DNA nanotechnology has seen large developments over the last 30 years through the
combination of solid phase synthesis and the discovery of DNA nanostructures. Solid phase …

Robotic DNA nanostructures

S Nummelin, B Shen, P Piskunen, Q Liu… - ACS Synthetic …, 2020 - ACS Publications
Over the past decade, DNA nanotechnology has spawned a broad variety of functional
nanostructures tailored toward the enabled state at which applications are coming …

A reversibly gated protein-transporting membrane channel made of DNA

S Dey, A Dorey, L Abraham, Y Xing, I Zhang… - Nature …, 2022 - nature.com
Controlled transport of biomolecules across lipid bilayer membranes is of profound
significance in biological processes. In cells, cargo exchange is mediated by dedicated …

Reconfigurable DNA origami nanocapsule for pH-controlled encapsulation and display of cargo

H Ijäs, I Hakaste, B Shen, MA Kostiainen, V Linko - ACS nano, 2019 - ACS Publications
DNA nanotechnology provides a toolbox for creating custom and precise nanostructures
with nanometer-level accuracy. These nano-objects are often static by nature and serve as …

Recent advances of metal-based nanoparticles in nucleic acid delivery for therapeutic applications

AR Sharma, YH Lee, A Bat-Ulzii… - Journal of …, 2022 - Springer
Recent efforts in designing nanomaterials to deliver potential therapeutics to the targeted
site are overwhelming and palpable. Engineering nanomaterials to deliver biological …

Net-shaped DNA nanostructures designed for rapid/sensitive detection and potential inhibition of the SARS-CoV-2 virus

N Chauhan, Y Xiong, S Ren, A Dwivedy… - Journal of the …, 2022 - ACS Publications
We present a net-shaped DNA nanostructure (called “DNA Net” herein) design strategy for
selective recognition and high-affinity capture of intact SARS-CoV-2 virions through spatial …

Self-assembly of organic nanomaterials and biomaterials: The bottom-up approach for functional nanostructures formation and advanced applications

D Lombardo, P Calandra, L Pasqua, S Magazù - Materials, 2020 - mdpi.com
In this paper, we survey recent advances in the self-assembly processes of novel functional
platforms for nanomaterials and biomaterials applications. We provide an organized …