The use of β-blockers (BB) in heart failure (HF) has been considered a contradiction for
many years. Considering HF simply as a state of inadequate systolic function, BB were …

Aims β-Blockers reduce mortality and morbidity in heart failure. Many of their benefits can be
explained solely by heart rate reduction (HRR). We aimed to verify whether the β-blocker …

The concept of cardiorenal syndrome (CRS) is derived from the crosstalk between the heart
and kidneys in pathological conditions. Despite the rising importance of CRS, there is a …

We tested the hypothesis that heart rate (HR) reduction, induced by the selective
hyperpolarization-activated current inhibitor ivabradine (Iva), might improve left ventricular …

Background—Impaired angiogenesis in the post-myocardial infarction heart contributes to
the progression to heart failure. The inhibition of vascular endothelial growth factor (VEGF) …

We tested the hypothesis that chronically reducing the heart rate in infarcted middle-aged
rats using ivabradine (IVA) would induce arteriolar growth and attenuate perivascular …

Objective The aims of this study were, first, to determine if granulocyte colony-stimulating
factor (G-CSF) and stem cell factor (SCF) improved left ventricular function in the setting of a …

Objective Platelet activation and subsequent release of granules containing a variety of
growth factors, at the site of injury, is crucial for the wound healing process. We postulated …

Objective—PDGF and FGF-2 are important regulators of vascular wall assembly. We tested
the hypothesis that their embryonic temporal expression facilitates 2 specific events:(1) the …

Aim Renal denervation (RDN) has beneficial effects on cardiac remodelling and function in
resistant hypertension. We aimed to investigate the impact of RDN on cardiac angiogenesis …