Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

Cellular ROS production participates in various cellular functions but its accumulation
decides the cell fate. Malignant cells have higher levels of ROS and active antioxidant …

Phagocytosis is required for the optimal efficacy of many approved and promising
therapeutic antibodies for various malignancies. However, the factors that determine the …

T-cell acute lymphoblastic leukemia (T-ALL) is characterized as a high-risk stratified disease
associated with frequent relapse, chemotherapy resistance, and a poorer prognostic outlook …

Compromised immunosurveillance leads to chemotherapy resistance and disease relapse
of hematological malignancies. Amino acid metabolism regulates immune responses and …

The failure in effective cancer treatment is thought to be attributed to a subpopulation of
tumor cells with stem cell-like properties. These cancer stem cells (CSCs) are intimately …

The Notch signaling pathway regulates cell proliferation, cytodifferentiation and cell fate
decisions in both embryonic and adult life. Several aspects of stem cell maintenance are …

T cell acute lymphoblastic leukaemia (T-ALL) is an aggressive malignancy with poor
prognosis, but a decisive marker and effective treatment for leukaemia stem cells (LSCs) …

The Wnt signaling pathway has been shown to play important roles in normal hematopoietic
stem cell biology and in the development of both acute and chronic myelogenous leukemia …

T-cell acute lymphoblastic leukemia (T-ALL) constitutes an aggressive subset of ALL, the
most frequent childhood malignancy. Whereas interleukin-7 (IL-7) is essential for normal T …