Pulmonary surfactant: a mighty thin film

F Possmayer, YY Zuo, RAW Veldhuizen… - Chemical …, 2023 - ACS Publications
Pulmonary surfactant is a critical component of lung function in healthy individuals. It
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing …

[HTML][HTML] The role of lipids in pulmonary surfactant

R Veldhuizen, K Nag, S Orgeig, F Possmayer - Biochimica et Biophysica …, 1998 - Elsevier
Pulmonary surfactant is composed of approx. 90% lipids and 10% protein. This review
article focusses on the lipid components of surfactant. The first sections will describe the lipid …

[HTML][HTML] Structure-function relationships in pulmonary surfactant membranes: from biophysics to therapy

E Lopez-Rodriguez, J Pérez-Gil - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
Pulmonary surfactant is an essential lipid–protein complex to maintain an operative
respiratory surface at the mammalian lungs. It reduces surface tension at the alveolar air …

[HTML][HTML] Structure of pulmonary surfactant membranes and films: the role of proteins and lipid–protein interactions

J Pérez-Gil - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2008 - Elsevier
The pulmonary surfactant system constitutes an excellent example of how dynamic
membrane polymorphism governs some biological functions through specific lipid–lipid …

Autoimmune pulmonary alveolar proteinosis

C McCarthy, BC Carey, BC Trapnell - American journal of …, 2022 - atsjournals.org
Autoimmune pulmonary alveolar proteinosis (PAP) is a rare disease characterized by
myeloid cell dysfunction, abnormal pulmonary surfactant accumulation, and innate immune …

Cholesterol rules: direct observation of the coexistence of two fluid phases in native pulmonary surfactant membranes at physiological temperatures

JB de la Serna, J Perez-Gil, AC Simonsen… - Journal of Biological …, 2004 - ASBMB
Pulmonary surfactant, the lipid-protein material that stabilizes the respiratory surface of the
lungs, contains approximately equimolar amounts of saturated and unsaturated …

Pulmonary surfactant: the key to the evolution of air breathing

CB Daniels, S Orgeig - Physiology, 2003 - journals.physiology.org
Pulmonary surfactant controls the surface tension at the air-liquid interface within the lung.
This system had a single evolutionary origin that predates the evolution of the vertebrates …

Biochemical and pharmacological differences between preparations of exogenous natural surfactant used to treat Respiratory Distress Syndrome: role of the different …

O Blanco, J Pérez-Gil - European journal of pharmacology, 2007 - Elsevier
The pharmaceutical application of exogenous natural pulmonary surfactant preparations
has shown its efficiency in the therapeutical treatment of infants with Respiratory Distress …

Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis

C McCarthy, E Lee, JP Bridges, A Sallese… - Nature …, 2018 - nature.com
Pulmonary alveolar proteinosis (PAP) is a syndrome of reduced GM-CSF-dependent,
macrophage-mediated surfactant clearance, dysfunctional foamy alveolar macrophages …

Targeting cholesterol homeostasis in lung diseases

A Sallese, T Suzuki, C McCarthy, J Bridges, A Filuta… - Scientific reports, 2017 - nature.com
Macrophages are critical to organ structure and function in health and disease. To determine
mechanisms by which granulocyte/macrophage-colony stimulating factor (GM-CSF) …