The study of botulinum neurotoxins (BoNT) is rapidly progressing in many aspects. Novel
BoNTs are being discovered owing to next generation sequencing, but their biologic and …

Botulinum neurotoxin (BoNT), the causative agent of botulism, is acknowledged to be the
most poisonous protein known. BoNT proteases disable synaptic vesicle exocytosis by …

Clostridium botulinum, a polyphyletic Gram-positive taxon of bacteria, is classified purely by
their ability to produce botulinum neurotoxin (BoNT). BoNT is the primary virulence factor …

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the
classical structure-function paradigm that equates function with a well-defined 3D structure …

Botulinum neurotoxins (BoNTs) are highly poisonous substances that are also effective
medicines. Accidental BoNT poisoning often occurs through ingestion of Clostridium …

Botulinum neurotoxins (BoNTs) cause flaccid paralysis by interfering with vesicle fusion and
neurotransmitter release in the neuronal cells. BoNTs are the most widely used therapeutic …

Tetanus neurotoxin and botulinum neurotoxins are the causative agents of tetanus and
botulism. They block the release of neurotransmitters from synaptic vesicles in susceptible …

Botulinum neurotoxins (BoNT) cause the disease botulism, a flaccid paralysis of the muscle.
They are also very effective, widely used medicines applied locally in sub-nanogram …

Clostridium botulinum produces seven antigenically distinct neurotoxins [C. botulinum
neurotoxins (BoNTs) A–G] sharing a significant sequence homology. Based on sequence …

The tetanus neurotoxin (Te NT) is a highly potent toxin produced by Clostridium tetani that
inhibits neurotransmission of inhibitory interneurons, causing spastic paralysis in the tetanus …