[HTML][HTML] Merkel cell carcinoma: epidemiology, prognosis, therapy and unmet medical needs

D Schadendorf, C Lebbé, A Zur Hausen… - European journal of …, 2017 - Elsevier
Merkel cell carcinoma (MCC) is a rare skin cancer that is associated with Merkel cell
polyomavirus infection in most cases. Incidence rates of MCC have increased in past …

Non-melanoma skin cancers: Biological and clinical features

M Cives, F Mannavola, L Lospalluti, MC Sergi… - International Journal of …, 2020 - mdpi.com
Non-melanoma skin cancers (NMSCs) include basal cell carcinoma (BCC), squamous cell
carcinoma (SCC) and Merkel cell carcinoma (MCC). These neoplasms are highly diverse in …

Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial

HL Kaufman, J Russell, O Hamid, S Bhatia… - The lancet …, 2016 - thelancet.com
Background Merkel cell carcinoma is a rare, aggressive skin cancer with poor prognosis in
patients with advanced disease. Current standard care uses various cytotoxic chemotherapy …

PD-1 blockade with pembrolizumab in advanced Merkel-cell carcinoma

PT Nghiem, S Bhatia, EJ Lipson… - … England Journal of …, 2016 - Mass Medical Soc
Background Merkel-cell carcinoma is an aggressive skin cancer that is linked to exposure to
ultraviolet light and the Merkel-cell polyomavirus (MCPyV). Advanced Merkel-cell carcinoma …

Merkel cell carcinoma, version 1.2018, NCCN clinical practice guidelines in oncology

CK Bichakjian, T Olencki, SZ Aasi, M Alam… - Journal of the National …, 2018 - jnccn.org
This selection from the NCCN Guidelines for Merkel Cell Carcinoma (MCC) focuses on
areas impacted by recently emerging data, including sections describing MCC risk factors …

Response rates and durability of chemotherapy among 62 patients with metastatic Merkel cell carcinoma

JG Iyer, A Blom, R Doumani, C Lewis… - Cancer …, 2016 - Wiley Online Library
Cytotoxic chemotherapy is commonly used to treat advanced Merkel cell carcinoma (MCC).
However, its efficacy in distant metastatic MCC patients is unclear, in part because most …

The genomic landscape of Merkel cell carcinoma and clinicogenomic biomarkers of response to immune checkpoint inhibitor therapy

TC Knepper, M Montesion, JS Russell, ES Sokol… - Clinical Cancer …, 2019 - AACR
Purpose: Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy, which
has demonstrated sensitivity to immune checkpoint inhibitor therapy. Here, we perform the …

[HTML][HTML] Diagnosis and treatment of Merkel Cell Carcinoma. European consensus-based interdisciplinary guideline

C Lebbe, JC Becker, JJ Grob, J Malvehy… - European journal of …, 2015 - Elsevier
Merkel cell carcinoma (MCC) is a rare tumour of the skin of neuro-endocrine origin probably
developing from neuronal mechanoreceptors. A collaborative group of multidisciplinary …

Merkel cell carcinoma: prognosis and treatment of patients from a single institution

PJ Allen, WB Bowne, DP Jaques… - Journal of clinical …, 2005 - ascopubs.org
Purpose Merkel cell carcinoma (MCC) is an uncommon cutaneous malignancy. Most reports
consist of single-institution experiences of fewer than 30 patients. The natural history of MCC …

Adjuvant radiation therapy and chemotherapy in Merkel cell carcinoma: survival analyses of 6908 cases from the National Cancer Data Base

S Bhatia, BE Storer, JG Iyer, A Moshiri… - JNCI: Journal of the …, 2016 - academic.oup.com
Background: Merkel cell carcinoma (MCC) has a high risk of recurrence after initial surgical
therapy. Adjuvant radiation therapy (RT) and chemotherapy may be used to reduce the risk …